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首页> 外文会议>National Conference on Biomedical Engineering;International Iranian Conference on Biomedical Engineering >Comparison of the Effect of EDC and Glutaraldehyde as Cross-linkers on Morphology and Swelling Ratio of Gelatin/Chitosan Scaffolds for Use in Skin Tissue Engineering
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Comparison of the Effect of EDC and Glutaraldehyde as Cross-linkers on Morphology and Swelling Ratio of Gelatin/Chitosan Scaffolds for Use in Skin Tissue Engineering

机译：EDC和戊二醛作为交联剂对皮肤组织工程用明胶/壳聚糖支架的形态和溶胀率的影响比较

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摘要

Skin is the body's largest organ, the first layer protecting the internal organs of the body from external damages. Because of this, the skin is exposed to many injuries, which, if severe, will require external intervention for treatment. One of the methods for treating severe skin lesions is tissue engineering. In the present study, chitosan and gelatin in three different ratios are utilized to skin scaffold construction and the effect of EDC and two different percentages of Glutaraldehyde as cross-linkers on morphology and swelling ratio of the mentioned scaffolds has been investigated. The results indicate that in general, the pores in the samples cross-linked by Glutaraldehyde are more uniform than those cross-linked by EDC and the samples immersed in EDC solution, have a layered structure. Furthermore, it can be concluded that in the samples cross-linked by EDC, increasing the ratio of gelatin to chitosan, reduces the average pore size, the percentage of porosity, swelling ratio, and water uptake of them, which is reversed in the samples containing Glutaraldehyde. In addition, the results show that by increasing the percentage of Glutaraldehyde from 0.01% to 0.02%, the water uptake and swelling ratio of the samples increase.
机译：皮肤是人体最大的器官，第一层保护身体的内部器官免受外部损害。因此，皮肤容易受到许多伤害，如果严重，将需要外部干预进行治疗。组织工程是治疗严重皮肤损伤的方法之一。在本研究中，以三种不同比例的壳聚糖和明胶用于皮肤支架的构建，并且研究了EDC和两种不同百分比的戊二醛作为交联剂对所述支架的形态和溶胀率的影响。结果表明，与戊二醛交联的样品相比，戊二醛交联的样品中的孔更均匀，浸入EDC溶液中的样品具有层状结构。此外，可以得出结论，在通过EDC交联的样品中，增加明胶与壳聚糖的比例，降低它们的平均孔径，孔隙率百分比，溶胀率和吸水率，这在样品中是相反的含有戊二醛。另外，结果表明，通过将戊二醛的百分比从0.01％增加到0.02％，样品的吸水率和溶胀率增加。

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