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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Mendelian Randomization of Arsenic Metabolism as a Risk Factor for Hypertensive- and Diabetes-Related Traits among Adults in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Cohort
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Mendelian Randomization of Arsenic Metabolism as a Risk Factor for Hypertensive- and Diabetes-Related Traits among Adults in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Cohort

机译：在西班牙裔社区健康研究/拉丁裔（HCHS / SOL）队列研究中，孟德尔随机将砷代谢作为成人高血压和糖尿病相关性状的危险因素

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Much of the research that connects hypertension and diabetes to arsenic has been conducted in populations exposed through drinking water. Recently, dietary rice has been recognized as a significant source of arsenic. The objective of this analysis was to evaluate whether arsenic metabolism efficiency is associated with hypertension and diabetes using a Mendelian randomization framework in a population with high rice consumption but no known water arsenic exposure. Using 12,689 participants from the Hispanic Community Health Study/Study of Latinos, this study examined the relationship between estimated arsenic metabolism efficiency (defined as the percentages of inorganic arsenic, monomethylarsenate (MMA), and dimethylarsinate (DMA) species) and three hypertensive traits and seven diabetes-related traits. The analyses implemented a two-stage Mendelian randomization approach, with the genotype-arsenic metabolism relationships extracted from published literature, and the genotype-trait relationships estimated from a mixed-effect linear model within the HCHS/SOL population that controlled for the complex survey design and admixed ancestry. The analysis was stratified by rice consumption, dichotomized at the top 10th percentile. Among high consumers of rice, each estimated percentage point increase in MMA was associated with increases of 1.08 mmHg in systolic blood pressure and 0.82 mmHg in diastolic (p=0.047 and 0.0167, respectively). Inorganic arsenic was similarly associated with increased diastolic blood pressure (1.1 mmHg/percentage point; p=0.021). DMA, which represents more efficient arsenic metabolism, was associated with lowered diastolic blood pressure (-0.5 mmHg/percentage point; p=0.017). Among low rice consumers, no associations were observed. Evidence for a relationship with diabetes was equivocal. This suggests that dietary arsenic exposure through rice may be a contributor to high blood pressure in the Hispanic/Latino community.
机译：将高血压和糖尿病与砷联系起来的许多研究都是在通过饮用水暴露的人群中进行的。最近，饮食大米已被认为是砷的重要来源。这项分析的目的是使用孟德尔随机框架评估水稻消费量高但无水砷暴露的人群中砷的代谢效率是否与高血压和糖尿病有关。使用来自拉美裔裔西班牙裔社区健康研究/研究的12689名参与者，本研究检查了估计的砷代谢效率（定义为无机砷，一甲基砷酸盐（MMA）和二甲基砷酸盐（DMA）种类的百分比）与三种高血压性状之间的关系。七个与糖尿病有关的特征。分析采用两阶段孟德尔随机化方法，从已发表的文献中提取基因型-砷代谢关系，并从控制复杂调查设计的HCHS / SOL人群中的混合效应线性模型估算基因型-性状关系。和混合的祖先。该分析按大米消耗量进行了分层，排在前十个百分位。在大米消费国中，MMA估计的每增加一个百分点，收缩压就会增加1.08 mmHg，舒张压增加0.82 mmHg（分别为p = 0.047和0.0167）。无机砷与舒张压升高有关（1.1 mmHg /百分点; p = 0.021）。代表更有效的砷代谢的DMA与舒张压降低有关（-0.5 mmHg /百分点; p = 0.017）。在稻米消费量低的消费者中，没有发现关联。与糖尿病的关系的证据是模棱两可的。这表明在大米中饮食中砷的暴露可能是西班牙裔/拉丁美洲裔社区高血压的一个原因。

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