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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Triggering of Neurodegenerative Hospital Admissions and Emergency Room Visits by Fine Particle Concentrations in Six Urban Centers in New York State: The New York State Accountability Study
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Triggering of Neurodegenerative Hospital Admissions and Emergency Room Visits by Fine Particle Concentrations in Six Urban Centers in New York State: The New York State Accountability Study

机译：纽约州六个城市中心的细颗粒物浓度触发神经变性医院入院和急诊室就诊：纽约州问责制研究

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Emerging evidence has linked exposure to ambient fine particle (PM2.5) concentrations with an increased incidence of neurodegenerative conditions such as dementia, Alzheimer's disease (AD), and Parkinson's disease (PD). Previous studies have not examined the association between ambient PM2.5 concentrations and exacerbations of symptoms, which would further add to the public health burden of these chronic neurodegenerative conditions. Using the Statewide Planning and Research Cooperative System (SPARCS) database, we retrieved all hospital admissions (inpatient) and emergency room visits (outpatient) with a primary diagnosis of one of three neurodegenerative disease subtypes for NYS residents living within 15 miles from PM2.5 monitoring sites in Buffalo, Rochester, Albany, Queens, Bronx, and Manhattan from 2005-2016. Using quasi-Poisson regression models adjusting for temperature, relative humidity, and secular trends in hospitalization rates, we examined the association between daily inpatient and outpatient neurodegenerative hospitalizations and ambient PM2.5 concentrations estimated for short-term and long-term time windows: concurrent exposure as well as lagged by 14, 30,180, and 365 days. A total of 63,287 inpatient admissions and 14,288 outpatient visits for the three neurodegenerative conditions occurred during the study period. Interquartile range (IQR) increases in PM2.5 concentration were not associated with increased rates of inpatient AD and dementia hospitalizations. However, increased rates of PD hospital admissions were associated with increased PM2.5 concentrations in the previous 14 days (rate ratio (RR) = 1.04; 95% confidence interval (CI) = 1.00-1.09), and 30 days (RR=1.06; 95% Cl=1.00-1.12). For outpatient visits, an increased rate of AD was associated with increased PM2.5 in the past 365 days (RR=1.77; 95% CI = 1.03-3.03). Thus, ambient PM2.5 exposure may be associated with exacerbations of symptoms among patients with neurodegenerative disease.
机译：新兴的证据具有与痴呆，阿尔茨海默病（AD）和帕金森病（PD）等神经变性条件（如痴呆症）的发病率增加了暴露于环境细颗粒（PM2.5）浓度。以前的研究没有检查环境PM2.5之间的关联和症状的恶化，这将进一步增加这些慢性神经变性条件的公共卫生负担。使用州所有规划和研究合作系统（SPARCS）数据库，我们检索了所有医院入学（住院）和急诊室访问（门诊），初级诊断为距离PM2.5 15英里范围内的NYS居民的三个神经退行性疾病亚型中的一种从2005 - 2016年从水牛城，罗切斯特，奥尔巴尼，皇后区，布朗克斯和曼哈顿的监测网站。使用调整温度，相对湿度和住院费率的世俗趋势的准泊松回归模型，我们研究了日常住院患者和门诊神奇再生住院治疗和环境PM2.5绩效之间的关联，估计短期和长期时间窗口：并发暴露以及14,30,180和365天的滞后。在研究期间，共有63,287名住院入住入院和14,288名门诊观察三个神经变性条件。 PM2.5的狭隘范围（IQR）增加了PM2.5浓度与住院性广告和痴呆症率的增加无关。然而，在过去的14天内，Pd医院入院的增加的PD医院入学率增加了PM2.5浓度（率比（RR）= 1.04; 95％置信区间（CI）= 1.00-1.09）和30天（RR = 1.06 ; 95％cl = 1.00-1.12）。对于门诊到访，过去365天的PM2.5增加了增加的PM2.5（RR = 1.77; 95％CI = 1.03-3.03）。因此，环境PM2.5暴露可能与神经退行性疾病患者的症状的恶化相关。

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