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Effects of Prenatal Exposure to Phthalates on Neonatal Birth Weight: SHK Birth Cohort

机译：产前暴露于邻苯二甲酸盐对新生儿出生体重的影响：SHK出生队列

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Phthalates exposure were associated with lower birth weight. However, there's limited data on whether phthalates could affect birth weight directly or indirectly through gestational age and pregnancy syndrome. To evaluate the effects of prenatal exposure to phthalates on birth weight in neonates, 181 mother-newborn pairs were recruited from SHK birth cohort. Maternal urine samples were collected during the third trimester and measured for phthalate metabolites by the method of ESI -MS/MS. Structural equation models (SEM) were used to evaluate the direct effect of phthalate on birth weight controlling for maternal education, monthly income, nutritional supplements, infant gender and maternal weight gain per week. The potential indirect effects of phthalate exposure through gestational age on birth weight, as well as the potential indirect effect through pregnancy syndrome were also calculated by SEM method. After adjusting for all mediators, urinary phthalate levels were negatively associated with birth weight. An increasing ten-fold concentration of MEOHP and MEHHP would directly reduce birth weight in 124g and 107g, respectively. However, MBP had indirect effect on birth weight through gestational age, which caused an 85g reduction for every unit increase in log-transformed exposure. Both direct and indirect effects on birth weight were found in MMP and MEHP. The indirect effects of MMP and MEHP were mediated through gestational age and pregnancy syndrome. Totally, prenatal MMP and MEHP exposure were associated with 96g and 61g decreased birth weight, respectively. There's a negative association between prenatal phthalate exposure and birth weight in Chinese neonates. Besides direct pathway, phthalate exposures could affect birth weight through the mediating effects of gestational age and pregnancy syndrome.
机译：邻苯二甲酸盐的暴露与较低的出生体重有关。但是，关于邻苯二甲酸盐是否会通过胎龄和妊娠综合症直接或间接影响出生体重的数据有限。为了评估产前暴露于邻苯二甲酸盐对新生儿出生体重的影响，从SHK出生队列中招募了181对母婴。在孕晚期收集孕妇尿液样品，并通过ESI -MS / MS方法测定邻苯二甲酸酯代谢物。使用结构方程模型（SEM）评估邻苯二甲酸盐对控制孕产妇体重，每月收入，营养补充品，婴儿性别和每周孕产妇体重增加的直接作用。还通过SEM方法计算了通过胎龄暴露邻苯二甲酸盐对出生体重的潜在间接影响，以及通过妊娠综合征引起的潜在间接影响。调整所有介质后，尿中邻苯二甲酸酯水平与出生体重呈负相关。浓度增加十倍的MEOHP和MEHHP将分别直接减轻出生体重124g和107g。然而，MBP对整个胎龄的出生体重都有间接影响，对数转换后的暴露量每增加一单位，MBP减少85g。在MMP和MEHP中发现了对出生体重的直接和间接影响。 MMP和MEHP的间接作用是通过胎龄和妊娠综合症介导的。总体而言，产前MMP和MEHP暴露分别与出生体重下降96g和61g有关。中国新生儿的产前邻苯二甲酸酯暴露与出生体重之间存在负相关关系。除了直接途径外，邻苯二甲酸盐的暴露还可以通过胎龄和妊娠综合征的介导作用影响出生体重。

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    《》|2018年|1843-1843|共1页
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    Yunhui Zhang;

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