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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Breast Cancer Risk by Occupation in Females and Males in Ontario, Canada: Results from the Occupational Disease Surveillance System (ODSS), 1983-2016
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Breast Cancer Risk by Occupation in Females and Males in Ontario, Canada: Results from the Occupational Disease Surveillance System (ODSS), 1983-2016

机译：加拿大安大略省男性和女性按职业划分的乳腺癌风险：职业病监测系统（ODSS）的结果，1983-2016年

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Background: While breast cancer is one of the most commonly diagnosed cancers among women, it accounts for fewer than 1% of cancer cases in men worldwide. Few prior studies have been able to study breast cancer in working men. This study uses data from the recently established Occupational Disease Surveillance System (ODSS) to examine risk of breast cancer in both women and men across different occupation groups. Methods: The ODSS was established through the linkage of existing administrative data and contains information on 2,190,246 Ontario workers (1983-2016). Workers were followed up for breast cancer diagnosis in the Ontario Cancer Registry (OCR). Cox-proportional hazard models were used to calculate age-adjusted hazard ratios (HR) and 95% confidence intervals (CI). Results: A total of 17, 865 and 492 breast cancer cases were identified in working women and men, respectively. Across both sexes, statistically significant (p<0.05) elevated risks were observed in management (w: HR 1.57, 95% CI 1.42-1.73; m: HR 2.41, 95% CI 1.24-4.66), administrative and clerical (w: HR 1.16, 95% CI 1.11-1.21; m: HR 1.56, 95% CI 1.13-2.13), and teaching occupations (w: HR 1.49, 95% CI 1.41-1.59; m: HR 2.82, 95% CI 1.40-5.66). Other statistically significant elevated risks were observed in social sciences, nursing and other health, transport and equipment operating, and sales commodity occupations for both sexes. Conclusions: Similar findings were found in women and men that warrant further investigation into job-related factors, such as sedentary behaviour, stress, shift work, and for some occupations, radiation exposure. The findings from this study, if validated in other study samples, may help focus breast cancer prevention and education efforts for both females and males.
机译：背景：虽然乳腺癌是女性中最常被诊断出的癌症之一，但它仅占全世界男性癌症病例的不到1％。很少有先前的研究能够研究在职男性的乳腺癌。这项研究使用了最近建立的职业病监测系统（ODSS）的数据，以检查不同职业群体中男女的乳腺癌风险。方法：ODSS是通过现有行政数据的链接建立的，其中包含有关2,190,246名安大略省工人的信息（1983-2016年）。在安大略省癌症登记处（OCR）对工人进行了乳腺癌诊断的随访。使用Cox比例风险模型来计算年龄调整后的风险比（HR）和95％置信区间（CI）。结果：在职业女性和男性中分别鉴定出17 865例和492例乳腺癌。在行政和文书管理方面（W：HR），在男女中，管理上的风险都有统计学意义（p <0.05）升高（w：HR 1.57，95％CI 1.42-1.73; m：HR 2.41，95％CI 1.24-4.66） 1.16，95％CI 1.11-1.21; m：HR 1.56，95％CI 1.13-2.13）和教学职业（w：HR 1.49，95％CI 1.41-1.59; m：HR 2.82，95％CI 1.40-5.66） 。在社会科学，护理和其他健康，运输和设备操作以及男女销售商品职业中还观察到其他统计学上显着升高的风险。结论：在男性和女性中也发现了类似的发现，因此有必要进一步调查与工作相关的因素，例如久坐的行为，压力，轮班工作以及某些职业的辐射暴露。如果该研究的结果在其他研究样本中得到验证，则可能有助于集中针对女性和男性的乳腺癌预防和教育工作。

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