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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Sex/Gender Differences in Cardiovascular Mortality Associated with Environmental Stressors: Systematic Review and Meta-Analysis
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Sex/Gender Differences in Cardiovascular Mortality Associated with Environmental Stressors: Systematic Review and Meta-Analysis

机译：与环境压力相关的心血管疾病的性别差异：系统评价和荟萃分析

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Epidemiological studies of environmental stressors associated with cardiovascular health often show different effect estimates for males and females, but results are far from being consistent. Furthermore, there is a need to disentangle whether this modification is attributable to the biological sex, to gender including social role or cultural norms or an interplay of both. Our objective is to evaluate the current state of integrating sex/gender into environmental epidemiology and to quantify the sex/gender specific effects of ambient air pollution, air temperature and noise on cardiovascular mortality. We conducted a systematic literature search using the electronic databases PubMed and Web of Science (WOS). Publications in English or German between 2000 and 2017 which provide sex/gender specific effect estimates for short- and long-term associations between particulate matter with a diameter <2.5μm (PM2.5) and <10μm (PM10), nitrogen dioxide (NO2), ozone, air temperature as well as noise and cardiovascular mortality were screened. We will assess studies' integration of sex and gender with regard to conceptualization and operationalization of sex/gender, reporting of male and female specific baseline characteristics, exposure and health data as well as discussion of sex/gender specific results. After study quality rating sex/gender specific effects will be quantified by applying meta-analytic tools. Of 660 and 394 identified articles in PubMed and WOS, respectively, 76 studies met our inclusion criteria. Most studies dealt with PM2.5 (N=29), followed by PM10 (26), NO2 (26), air temperature (25) and Ozone (10). Only one study was found regarding noise. Preliminary results show that studies generally used a dichotomous category "male/female", lacked a clear conceptualization and therefore missed a gainful discussion of results. In the next steps we will continue with the extraction of necessary information and preparation of meta-analysis where possible.
机译：对与心血管健康有关的环境应激源的流行病学研究通常显示，对男性和女性的影响估计不同，但结果相差甚远。此外，有必要弄清这种修饰是否归因于生物性别，归因于包括社会角色或文化规范的性别或两者的相互作用。我们的目标是评估将性别/性别纳入环境流行病学的现状，并量化环境空气污染，气温和噪声对心血管疾病死亡率的性别/性别特定影响。我们使用电子数据库PubMed和Web of Science（WOS）进行了系统的文献检索。 2000年至2017年之间以英文或德文出版的出版物，提供了针对性别/性别的特定效应估计值，用于直径<2.5μm（PM2.5）和<10μm（PM10）的颗粒物，二氧化氮（NO2）之间的短期和长期关联），臭氧，气温以及噪音和心血管疾病的死亡率进行了筛查。我们将评估有关性别/性别概念化和可操作性，男性和女性特定基线特征的报告，接触和健康数据以及性别/性别特定结果的讨论等方面研究的性别整合。在研究质量评定后，将通过应用荟萃分析工具对性别/性别的特定影响进行量化。在PubMed和WOS分别鉴定的660和394条文章中，有76项研究符合我们的纳入标准。大多数研究涉及PM2.5（N = 29），其次是PM10（26），NO2（26），气温（25）和臭氧（10）。仅发现一项有关噪声的研究。初步结果表明，研究通常使用两分类别的“男性/女性”，缺乏明确的概念化，因此错过了对结果的有益讨论。在接下来的步骤中，我们将继续提取必要的信息，并在可能的情况下准备荟萃分析。

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