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Modifying brushite cement degradation using calcium alginate beads

机译：使用藻酸钙珠改善透钙磷石的降解

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The hydrolysis of brushite in calcium phosphate cements to form hydroxyapatite is known to result in the long term stability of the material in the body. It has previously been established that this hydrolysis reaction can be influenced by implant volume, media refreshment rate and media composition. In this study, the effect of macroporosity on the rate of degradation of the material is investigated. Macroporosity was incorporated into the material using calcium alginate beads mixed into the cement paste. The inclusion of the calcium alginate beads did not influence the degree of conversion of the material and allowed the incorporation of porosity at up to maximum of 57%. The macroporosity weakened the cement matrix (from 46.5 to 3.2 MPa). When aged the brushite in the macroporous cement dissolved completely from the matrix resulting in a weight loss of 60wt% in a period of 28 days. This suggests that the controlled incorporation of calcium alginate beads into brushite cements in vivo can be used to control implant degradation rate.
机译：已知钙磷灰石中透钙磷石的水解以形成羟基磷灰石会导致该物质在体内的长期稳定性。先前已经确定，该水解反应可受植入物的体积，介质的刷新率和介质组成的影响。在这项研究中，研究了大孔隙率对材料降解速率的影响。使用混入水泥浆中的海藻酸钙小珠将大孔隙度掺入材料中。包含藻酸钙珠粒不影响材料的转化程度，并且允许以最大57％的最大值引入孔隙率。大孔隙度削弱了水泥基质（从46.5到3.2 MPa）。当老化时，大孔水泥中的透钙磷石完全从基质中溶解，导致28天的重量损失为60wt％。这表明在体内将藻酸钙珠粒受控地掺入透钙磷石胶结剂可用于控制植入物的降解速率。

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