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首页> 外文会议>Bioceramics >Repairing Segmental Defect with a Composite Associating Collagen Membrane and MBCP~R Combined with Total Bone Marrow Graft in Irradiated Bone Defect: an Experimental Study in Rabbit
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Repairing Segmental Defect with a Composite Associating Collagen Membrane and MBCP~R Combined with Total Bone Marrow Graft in Irradiated Bone Defect: an Experimental Study in Rabbit

机译：胶原膜联合MBCP〜R联合全骨髓移植修复放射性骨缺损的节段性缺损：兔实验研究

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The aim of this study was to study bone marrow quality from various location and species for reconstruction of segmental critical size defect in irradiated weigh bearing bone. Sample of bone marrow aspirates from rabbits and Beagle dog were analyzed. Rabbits were implanted with a composite associating resorbable collagen membrane plus micro macroporous biphasic calcium phosphate (MBCP~R) and autologous bone marrow (BM) injected after irradiation. Bone marrow samples were found to be significantly less rich in tibia than in humerus and ilium in Dog and less rich in Dog than in Rabbit (p < 0,05). Successful osseous colonization bridging of the defect were obtain at 16 weeks in all animals. Identical repartition of bone ingrowth and residual ceramic at the different levels of the implant suggest an osteoinduction role of the bone marrow graft in the center of the defect. This model succeeded in reconstruct a large segmental defect in weight bearing and irradiated bone in rabbit.
机译：这项研究的目的是研究来自不同位置和物种的骨髓质量，以重建受辐照负重骨的节段性临界尺寸缺损。分析了来自兔子和比格犬的骨髓抽吸物样品。兔在植入后植入复合的可吸收胶原膜，微孔双相磷酸钙（MBCP〜R）和自体骨髓（BM）组成的复合物。发现在狗中，骨髓样本中胫骨的丰富度显着低于肱骨和i骨，而在兔子中，其胫骨的丰富度则较兔子低（p <0.05）。在所有动物中，在第16周均获得了成功的骨缺损的骨定植桥接。在植入物的不同水平上骨向内生长和残留陶瓷的重新分配表明，在缺损中心，骨髓移植物具有骨诱导作用。该模型成功地重建了兔子的承重和辐照骨的大型节段性缺损。

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