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首页> 外文会议>International Symposium on Medical Measurements and Applications >Measurement of Arterial Young's Elastic Modulus using ARTSENS Pen
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Measurement of Arterial Young's Elastic Modulus using ARTSENS Pen

机译：使用ARTSENS笔测量动脉杨氏弹性模量

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Arterial Young's modulus (Y) is an important elastic property of the artery that quantifies the material stiffness. Several studies have demonstrated that the quantitative values of Y and its standard deviation could be potentially used as an independent predictor of coronary heart diseases. For reliable measurements of Y, accurate measurements of arterial diameter and wall thickness are required. Conventionally these arterial dimensions are measured by imaging systems that are not a viable option for large-scale screening due to their form factor and a high degree of complexity. In this work, we present a portable image-free ultrasound modality - ARTSENS Pen for measurement of Y. ARTSENS is an extensively validated technology that is capable of providing clinical standard measurements of arterial dimensions and stiffness. In this present work, we have demonstrated the capability of the ARTSENS to make accurate and repeatable measurements of Y. The performance of the device is validated through an in-vivo study on 15 subjects. The ARTSENS measurements of Y were repeatable over continuous cardiac cycles for all the recruited subjects (beat-to-beat variation < 6 %). The mean of Y measured for all the subjects was $262.8pm 99$ kPa. The accuracy of the system was evaluated by a comparative analysis against a reference B-mode imaging modality. Regression analysis of the data showed that the Y measurements that were taken by ARTSENS significantly correlated (r = 0.90, p < 0.001) to the reference system measurements. Bland Altman analysis indicated a strong degree of agreement between measurements taken by the two devices, with an insignificant difference (p = 0.32).
机译：动脉的杨氏模量（Y）是动脉的重要弹性属性，可量化材料的刚度。多项研究表明，Y的定量值及其标准偏差可以潜在地用作冠心病的独立预测因子。为了可靠地测量Y，需要精确测量动脉直径和壁厚。常规地，这些动脉尺寸是通过成像系统来测量的，由于它们的形状因数和高度的复杂性，因此对于大规模筛查不是可行的选择。在这项工作中，我们提出了一种便携式的无图像超声检查方式-用于测量Y的ARTSENS笔。ARTSENS是一项经过广泛验证的技术，能够提供临床标准的动脉尺寸和硬度测量值。在目前的工作中，我们已经证明了ARTSENS能够进行准确且可重复的Y测量的能力。通过对15位受试者进行的体内研究验证了该设备的性能。对于所有入组受试者，Y的ARTSENS测量值在连续心动周期上均可重复（心跳间差异<6 \％）。所有受试者测得的Y平均值为$ 262.8 \ pm 99 $ kPa。通过与参考B模式成像模态进行比较分析，评估了系统的准确性。数据的回归分析显示，ARTSENS进行的Y测量与参考系统测量显着相关（r = 0.90，p <0.001）。布兰德·奥特曼（Bland Altman）分析表明，两种设备进行的测量之间的一致性很高，差异不显着（p = 0.32）。

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