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首页> 外文会议>International Symposium on Medical Measurements and Applications >Non-Invasive Assessment of Local Pulse Wave Velocity as Function of Arterial Pressure
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Non-Invasive Assessment of Local Pulse Wave Velocity as Function of Arterial Pressure

机译：非侵入性评估局部脉搏波速度与动脉压的关系

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Arterial pressure or flow wave propagation velocity (pulse wave velocity [PWV]) is inherently dependent on arterial elastic characteristics and distending pressure. Assessment of instantaneous variation in PWV over the cardiac cycle can be noninvasively performed using established biomechanical models by measuring arterial pressure and diameter from the same site. In this work, we explore and validate the viability of a bi-modal probe for local evaluation of PWV variation over the cardiac cycle as a function of arterial pressure. The proposed probe employs singleelement ultrasound transducer (for diameter measurement) and tonometric sensor (for pressure measurement) integrated into a custom probe holder. An application-specific measurement system and dedicated algorithms were used for simultaneous assessment of the desired physiological waveforms. The optimized transducer arrangement in the proposed probe allowed reliable capture of high-fidelity pressure and diameter waveforms from a single arterial site. Real-time assessment of variation in local PWV as a function of arterial pressure was validated on 10 human subjects (age = 31 ± 6 years) using the developed prototype system. Local PWV was found to increase during the systolic phase of each cardiac cycle, and exhibits a non-linear relationship with the arterial pressure. Results from the performed pilot study demonstrated that the proposed ultrasound-tonometer based onepoint method could reliably capture the incremental local PWV over continuous cardiac cycles. Simultaneous assessment of instantaneous variation in arterial pressure, diameter and local PWV using the proposed bi-modal probe has the potential to accurately characterize the elastic behavior of arteries.
机译：动脉压或流波传播速度（脉搏波速度[PWV]）固有地取决于动脉的弹性特征和扩张压力。可以使用已建立的生物力学模型通过测量同一部位的动脉压和直径来无创地评估PWV在心动周期上的瞬时变化。在这项工作中，我们探索并验证了双模态探针的可行性，该探针可用于局部评估PWV在整个心动周期中随动脉压的变化。提出的探头采用集成到定制探头支架中的单元素超声换能器（用于直径测量）和眼压传感器（用于压力测量）。使用专用测量系统和专用算法来同时评估所需的生理波形。所提出的探头中的优化换能器布置允许从单个动脉位置可靠地捕获高保真压力和直径波形。使用开发的原型系统，在10位人类受试者（年龄= 31±6岁）上验证了局部PWV随动脉压变化的实时评估。发现局部PWV在每个心动周期的收缩期期间增加，并且表现出与动脉压的非线性关系。进行的先导研究的结果表明，基于超声眼压计的单点方法可以在连续的心动周期中可靠地捕获增量的局部PWV。使用提出的双峰探针同时评估动脉压，直径和局部PWV的瞬时变化，具有准确表征动脉弹性行为的潜力。

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