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On-The-Fly Rapid-Cooling Gelation of Microgel Beads in Centrifugal Microfluidic Device with Liquid Nitrogen

机译:液氮离心微流体装置中微凝胶珠的现场快速冷却凝胶

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This paper describes a new fabrication method of microgel beads crosslinked by rapid temperature change using a centrifugal microfluidic device with a heating system and liquid nitrogen. Previously, materials for fabricating microgel beads with centrifugal microfluidic systems is limited to only sodium alginate solution. By using our proposed method, microgel beads could be fabricated by rapidly cooling pre-gel droplet ejected by centrifugal force. We succeeded in fabricating agarose microgel beads by rapid gelation in the liquid nitrogen. Our fabrication method will expand the variety of materials for the centrifugal microfluidic microgel beads fabrication method and possible applications including biosensors, tissue engineering and drug delivery systems.
机译:本文描述了通过使用具有加热系统和液氮的离心微流体装置通过快速温度变化交联的微凝胶珠的新制造方法。以前,用于制造具有离心微流体系统的微凝胶珠的材料仅限于藻酸钠溶液。通过使用所提出的方法,可以通过快速冷却通过离心力弹出的预凝胶液滴来制造微凝胶珠。我们通过在液氮中快速凝胶化成功地制造琼脂糖微凝胶珠。我们的制造方法将扩大离心微流体微凝胶珠制品和可能的应用,包括生物传感器,组织工程和药物递送系统的各种材料。

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