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首页> 外文会议>Annual SVC Technical Conference >3D Electrospun Scaffolds for Vascular Graft Applications: Fine Tuning of Properties by Plasma-Assisted Etching and Coating
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3D Electrospun Scaffolds for Vascular Graft Applications: Fine Tuning of Properties by Plasma-Assisted Etching and Coating

机译：用于血管移植物应用的3D Electromun支架：通过等离子体辅助蚀刻和涂层进行精细调整性能

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Primary requirements for synthetic vascular prostheses are biocompatibility, bioactivity, and favorable morphological and mechanical properties. In this research electro spinning, plasma etching and plasma polymerization (PP) were combined to fulfill those criteria. More particularly, we aimed to create scaffolds for subsequent cell-seeding that possess optimal mechanical, morphological and surface-chemical properties in the luminal and media layers. The first set of scaffolds were random electrospun poly(ethylene terephthalate) (ePET) nano-fiber mats, which mimic the morphological and mechanical properties of the extracellular matrix of native blood vessels' lumen. Amine-rich thin PP coatings, deposited via capacitively coupled radio-frequency (r.f.) plasma, enabled confluent monolayer pre-end othelialization of the lumen. Regarding the media layer, ePET nano-fibers were radially highly oriented; in order to bring their mechanical properties in line with those of natural blood vessels, a substantial reduction in Young's modulus had to be attained. For this purpose three different plasma etching techniques were investigated: (i) atmospheric pressure ("HP") corona discharge in air; low-pressure (ii) r.f. discharge; and (iii) discharge in a microwave plasma asher, the latter two in pure oxygen (O_2), or O_2 mixture with Ar or CF_4. By far the best results were achieved using (iii): without visible damage to the fibers, changes in surface composition and drastically improved wettability resulted in improved adhesion and growth of smooth muscle cells.
机译：合成血管假体的主要要求是生物相容性，生物活性和有利的形态和机械性能。在该研究中，组合电镀，等离子体蚀刻和等离子体聚合（PP）以满足这些标准。更具体地，我们旨在产生用于随后的细胞播种的支架，该细胞播种具有在腔和介质层中具有最佳的机械，形态学和表面化学性质。第一组支架是随机电纺聚（乙二醇酯）（EPET）纳米纤维垫，其模仿原生血管内腔细胞外基质的形态和力学性能。富含胺的薄PP涂层，通过电容耦合射频（R.F.）等离子体沉积，使能腔内的汇合单层前近端化。关于介质层，EPET纳米纤维径向高度取向;为了使其机械性能与天然血管的机械性能符合，必须达到杨氏模量的大幅降低。为此目的，研究了三种不同的等离子体蚀刻技术：（i）空气中的大气压（“HP”）电晕放电;低压（ii）r.f.释放; （iii）在微波等离子体中排出，后两种在纯氧（O_2）中，或与Ar或Cf_4的O_2混合物。到目前为止，使用（III）实现最佳结果：没有对纤维的可见损伤，表面组成的变化和急剧改善的润湿性导致平滑肌细胞的粘附性和生长。

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