Controlled delivery of il-1 receptor antagonist from plga microspheres

机译：从PLGA微球控制IL-1受体拮抗剂的递送

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Interleukin-1 (IL-1) is a pleiotropic cytokine that is expressed in many tumor, stromal and immune cells. Its effects on tumor development are pleiotropic and diverse. It induces the expression of a wide array of products, including cytokines, growth factors and inflammatory mediators that may affect angiogenesis~1. Interleukin-1 receptor antagonist (IL-1Ra) is a natural 22-kDa inhibitor of IL-1 and can modulate the effects of IL-1. It binds to IL-1 receptors on various target cells with an affinity nearly equal to that of IL-1 withut inducing any biological responses. IL-lRa given in doses up to 100-fold in excess of IL-1, decreased the effects of IL-1~2.

机译：白细胞介素-1（IL-1）是在许多肿瘤，基质和免疫细胞中表达的抗脂肪细胞因子。它对肿瘤发育的影响是脂肪和多样化的。它诱导各种产品的表达，包括可能影响血管生成〜1的细胞因子，生长因子和炎症介质。白细胞介素-1受体拮抗剂（IL-1RA）是IL-1的天然22-KDA抑制剂，可以调节IL-1的作用。它与各种靶细胞上的IL-1受体结合，其亲和力几乎等于IL-1的冲泡诱导任何生物反应。 IL-LRA在多达100倍的剂量上给出超过IL-1，降低了IL-1〜2的影响。

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《International symposium on controlled release of bioactive materials》|2000年||共2页
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G.Lavi; R.N.Apte; C.Dinarello; S.Cohen;
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中图分类生物材料学;
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1. Controlled delivery of ganciclovir to the retina with drug-loaded Poly(d,L-lactide-co-glycolide) (PLGA) microspheres dispersed in PLGA-PEG-PLGA Gel: a novel intravitreal delivery system for the treatment of cytomegalovirus retinitis. [J] . Duvvuri S, Janoria KG, Pal D, Journal of ocular pharmacology and therapeutics: The official journal of the Association for Ocular Pharmacology and Therapeutics . 2007,第3期

机译：用分散在PLGA-PEG-PLGA凝胶中的载药聚（d，L-丙交酯-乙交酯）（PLGA）微球控制更昔洛韦向视网膜的递送：一种新型玻璃体内递送系统，用于治疗巨细胞病毒性视网膜炎。
2. Adenoviral delivery of IL-1 receptor antagonist abrogates disease activity during the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice. [J] . Hur W, Cho ML, Yoon SK, Immunology Letters . 2006,第2期

机译：IL-1受体拮抗剂的腺病毒传递消除了IL-1受体拮抗剂缺陷小鼠自身免疫性关节炎发展过程中的疾病活性。
3. Mouse IL-1 receptor antagonist isoforms: complementary DNA cloning and protein expression of intracellular isoform and tissue distribution of secreted and intracellular IL-1 receptor antagonist in vivo. [J] . C Gabay, B Porter, G Fantuzzi, The journal of immunology . 1997,第12期

机译：小鼠IL-1受体拮抗剂同工型：体内互补的DNA克隆和细胞内同工型的蛋白表达以及分泌和细胞内IL-1受体拮抗剂的组织分布。
4. Controlled delivery of il-1 receptor antagonist from plga microspheres [C] . G.Lavi, R.N.Apte, C.Dinarello, International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 2000

机译：从plga微球受控递送il-1受体拮抗剂
5. PLGA-PEG-PLGA microspheres as a delivery vehicle for antisense oligonucleotides to CTGF: Implications on post-surgical peritoneal adhesion prevention. [D] . Azeke, John Imuetinyan-Jesu, Jr. 2007

机译：PLGA-PEG-PLGA微球作为CTGF反义寡核苷酸的递送载体：对预防术后腹膜粘连的影响。
6. Local delivery of controlled-release simvastatin/PLGA/HAp microspheres enhances bone repair [O] . I-Chun Tai, Yin-Chih Fu, Chih-Kuang Wang, 2013

机译：控释辛伐他汀/ PLGA / HAp微球的局部递送可增强骨修复
7. Sustained delivery of il-1ra from plga microspheres attenuates IL-1β mediated inflammation in a cartilage tissue analog [O] . Gorth D.J., Strutz W., Mohanraj B., 2012

机译：从plga微球持续释放il-1ra可减轻软骨组织类似物中IL-1β介导的炎症

Controlled delivery of il-1 receptor antagonist from plga microspheres

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