Chitosan derivatives as intestinal absorption enhancers of hydrophilic macromolecular therapeutics

机译：壳聚糖衍生物作为亲水性大分子治疗剂的肠道吸收增强剂

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Peroral delivery of hydrophilic macromolecular therapeutics is a challenge to Drug Delivery scientists. The epithelial barrier appears to be one of the major factors, responsible for poor intestinal permeability and systemic absorption of these therapeutics after peroral administration.

机译：亲水性大分子治疗剂的运动产卵是对药物交付科学家的挑战。上皮屏障似乎是主要因素之一，负责肠道渗透性不良和这些治疗剂的全身吸收。

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《International symposium on controlled release of bioactive materials》|2000年||共2页
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M.Thanou; J.C.Verhoef; H.E.Junginger;
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中图分类生物材料学;
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1. Mono-N-carboxymethyl chitosan (MCC), a polyampholytic chitosan derivative, enhances the intestinal absorption of low molecular weight heparin across intestinal epithelia in vitro and in vivo. [J] . Thanou M, Nihot MT, Jansen M, Journal of pharmaceutical sciences. . 2001,第1期

机译：单-N-羧甲基壳聚糖（MCC）是一种多两性壳聚糖衍生物，在体外和体内均可增强低分子量肝素在肠道上皮中的肠道吸收。
2. Improvement of intestinal absorption of insulin and water-soluble macromolecular compounds by chitosan oligomers in rats. [J] . Gao Y, He L, Katsumi H, International Journal of Pharmaceutics . 2008,第1a2期

机译：壳聚糖低聚物改善大鼠肠道对胰岛素和水溶性高分子化合物的吸收。
3. Mechanistic Studies on the Absorption-Enhancing Effects of Gemini Surfactant on the Intestinal Absorption of Poorly Absorbed Hydrophilic Drugs in Rats [J] . Tammam Alama, Kosuke Kusamori, Masaki Morishita, Pharmaceutics . 2019,第4期

机译：双子表面活性剂增强大鼠吸收不良亲水药物肠道吸收的机理研究
4. Chitosan derivatives as intestinal absorption enhancers of hydrophilic macromolecular therapeutics [C] . M.Thanou, J.C.Verhoef, H.E.Junginger International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 2000

机译：壳聚糖衍生物作为亲水性大分子药物的肠道吸收促进剂
5. Novel mechanisms in the intestinal absorption of hydrophilic cationic drugs. [D] . Bourdet, David Louis. 2005

机译：亲水性阳离子药物在肠内吸收的新机制。
6. Mechanistic Studies on the Absorption-Enhancing Effects of Gemini Surfactant on the Intestinal Absorption of Poorly Absorbed Hydrophilic Drugs in Rats [O] . Tammam Alama, Kosuke Kusamori, Masaki Morishita, 2019

机译：双子表面活性剂对大鼠吸收不良亲水药物肠道吸收的机制研究
7. Methylated N-(4-N,N-Dimethylaminobenzyl) Chitosan, a Novel Chitosan Derivative, Enhances Paracellular Permeability Across Intestinal Epithelial Cells (Caco-2) [O] . Kowapradit, Jariya, Opanasopit, Praneet, Ngawhiranpat, Tanasait, 2008

机译：甲基化的N-（4-N，N-二甲基氨基苄基）壳聚糖是一种新型壳聚糖衍生物，可增强跨肠上皮细胞（Caco-2）的细胞通透性。

Chitosan derivatives as intestinal absorption enhancers of hydrophilic macromolecular therapeutics

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