Zero-order release by enzymatic degradation in matrix tablets of modified starch (contramid~direct R)

机译：通过改性淀粉的基质片中酶降解零阶释放（矛盾〜Direct r）

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The release of low solubility drugs from hydrophilic matrices has always been a challenge especially when zero-order profiels are desired. As it is the case also for drugs with pH dependant solubilities, diffusion mechanism alone falls short of giving linear release profiles. In such situations, a combination of diffusion and progressive matrix erosion was found most successful~1. Contramid being a starch based excipient~2, it can be degraded enzymatically by alpha-amylase at intestinal pH. The objective of this work was to demonstrate the potential of combining modified starch and alpha-amylase in a simple matrix tablet to release low solubility drugs following a zero-order kinetics.

机译：来自亲水基质的低溶解度药物的释放始终是一种挑战，特别是当需要零阶产品时。由于这种情况也是具有pH依赖性溶解度的药物，仅扩散机构缺少线性释放型材。在这种情况下，发现扩散和渐进基质侵蚀的组合最成功〜1。互连是基于淀粉的赋形剂〜2，它可以通过在肠pH下通过α-淀粉酶酶促酶促降解。这项工作的目的是证明在简单的基质片中组合改性淀粉和α-淀粉酶的可能性，以在零级动力学之后释放低溶解性药物。

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《International symposium on controlled release of bioactive materials》|2000年||共2页
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A.Desjardins; A.El-Jammal; A.Ferrada; A.Filiatrault; P.Ouadji;
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中图分类生物材料学;
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1. Quantitative interpretation of the deviation from 'zero-order kinetics for the release of Cyanocobalamin from a starch-based enzymatically degradable hydrogel [J] . Bajpai SK, Bajpai M, Saxena S, Journal of Macromolecular Science. Pure and Applied Chemistry . 2006,第8期

机译：从淀粉基可酶降解水凝胶中释放氰钴胺的'零级动力学'偏离的定量解释
2. Enzymatic degradation of cross-linked high amylose starch tablets and its effect on in vitro release of sodium diclofenac. [J] . Rahmouni M, Chouinard F, Nekka F, European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2001,第3期

机译：交联高直链淀粉淀粉片的酶促降解及其对双氯芬酸钠的体外释放影响。
3. Formulation and Optimization of Directly Compressible Isoniazid Modified Release Matrix Tablet [J] . M. C. GOHEL, R. K. PARIKH, M. N. PADSHALA, Indian journal of pharmaceutical sciences. . 2007,第5期

机译：可直接压制的异烟肼缓释基质片的配方及优化
4. Zero-order release by enzymatic degradation in matrix tablets of modified starch (contramid~direct R) [C] . A.Desjardins, A.El-Jammal, A.Ferrada, International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 2000

机译：改性淀粉基质片剂中酶促降解的零级释放（contramid〜direct R）
5. Zero-order release of aspirin and theophylline from novel synthesized methylcellulose succinate and hypromellose glutarate matrix tablets. [D] . Vaghasia, Brijeshkumar V. 2010

机译：从新型合成琥珀酸甲基纤维素和谷氨酸羟丙甲纤维素基质片剂中零级释放阿司匹林和茶碱。
6. Design and Comparative Evaluation of In-vitro Drug Release Pharmacokinetics and Gamma Scintigraphic Analysis of Controlled Release Tablets Using Novel pH Sensitive Starch and Modified Starch- acrylate Graft Copolymer Matrices [O] . Pankaj Kumar, Ashok Laxmanrao Ganure, Bharat Bhushan Subudhi, 2015

机译：使用新型pH敏感淀粉和改性丙烯酸-丙烯酸酯接枝共聚物基质的控释片的体外药物释放药代动力学和γ闪烁显像分析的设计和比较评估
7. Modified geometry three-layered tablet as a platform for class II drugs zero-order release system [O] . Abdullah Monahi Albogami, Mustafa E. Omer, Abdulkareem M. Al Bekairy, 2017

机译：改装几何三层平板电脑作为II类药物零阶释放系统的平台

Zero-order release by enzymatic degradation in matrix tablets of modified starch (contramid~direct R)

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