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DIFFERENT PHARMACOKINETICS OF NICOTINE FOLLOWING INTRAVENOUS ADMINISTRATION OF NICOTIN BASE AND NICOTINE HYDROGEN TARTARATE IN RATS

机译：在大鼠尼古丁碱和尼古丁氢气尼古丁碱基施用后尼古丁的不同药代动力学

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Pharmacokinetics of nicotine base and nicotine hydrogen tartarate in rats was studied following intravenous administration. NB exhibited higher and sustained plasma nicotine levels than NS. Some selected physicochemical properties and metabolic conversion were different between two compounds. Different metabolism and/or elimination appear to be primarily responsible for their different pharmacokinetics.

机译：研究静脉内给药后，研究了大鼠尼古丁基碱和尼古丁氢的药代动力学。 NB表现出高于NS的血浆含量高。一些选定的物理化学性质和代谢转化在两种化合物之间是不同的。不同的新陈代谢和/或消除似乎主要负责其不同的药代动力学。

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《Annual meeting of the Controlled Release Society》|2002年||共2页
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作者
Byunq Hwa Jung; Bong Chul Chung; Suk Jae Chung; Chang-Koo Shim;
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原文格式 PDF
正文语种
中图分类制药化学工业;
关键词
pharmacokinetics; nicotine; cotinine;

机译：药代动力学;尼古丁;cotinine;

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专利

1. 'Nicotine deprivation effect' in rats with intermittent 23-hour access to intravenous nicotine self-administration. [J] . ODell LE, Koob GF Pharmacology, Biochemistry and Behavior . 2007,第2期

机译：尼古丁剥夺效应在间歇性23小时静脉内自用尼古丁自我给药的大鼠中。
2. Plasma nicotine and cotinine levels following intravenous nicotine self-administration in rats. [J] . Shoaib M, Stolerman IP Psychopharmacology . 1999,第3期

机译：大鼠静脉内尼古丁自我给药后血浆尼古丁和可替宁水平。
3. Effect of menthol on nicotine intake and relapse vulnerability in a rat model of concurrent intravenous menthol/nicotine self-administration [J] . Nesil Tanseli, Narmeen Syeda, Bakhti-Suroosh Anousheh, Psychopharmacology . 2019,第4期

机译：薄荷醇对同时静脉内薄荷醇/尼古丁自主诊断大鼠尼古丁摄入和复发脆弱性的影响
4. DIFFERENT PHARMACOKINETICS OF NICOTINE FOLLOWING INTRAVENOUS ADMINISTRATION OF NICOTIN BASE AND NICOTINE HYDROGEN TARTARATE IN RATS [C] . Byunq Hwa Jung, Bong Chul Chung, Suk Jae Chung, Proceedings of the 29th Annual Meeting of the Controlled Release Society . 2002

机译：尼古丁碱和酒石酸尼古丁氢盐静脉内给药后不同剂量尼古丁的药代动力学
5. Heterogeneity of neuronal nicotinic acetylcholine receptors in rat nervous system and their differential regulation by chronic administration of nicotine. [D] . Mao, Danyan. 2007

机译：大鼠神经系统中神经元烟碱型乙酰胆碱受体的异质性及其对尼古丁的长期给药的差异调节。
6. Nicotine Deprivation Effect in Rats with Intermittent 23-hour Access to Intravenous Nicotine Self-Administration [O] . Laura E. O’Dell, George F. Koob -1

机译：间歇性23小时静脉内尼古丁自我管理大鼠的尼古丁剥夺作用
7. Nicotine Population Pharmacokinetics in Healthy Smokers After Intravenous, Oral, Buccal and Transdermal Administration [O] . Per O. Olsson Gisleskog, Juan José Perez Ruixo, Åke Westin, 2020

机译：尼古丁种群药代动力学在静脉内，口服，口服和透皮施用后健康吸烟者

DIFFERENT PHARMACOKINETICS OF NICOTINE FOLLOWING INTRAVENOUS ADMINISTRATION OF NICOTIN BASE AND NICOTINE HYDROGEN TARTARATE IN RATS

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