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首页> 外文会议>International Conference on Microchannels and Minichannels >AN INTEGRATED MICROFLUIDIC DIELECTROPHORETIC (DEP) CELL FRACTIONATION SYSTEM
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AN INTEGRATED MICROFLUIDIC DIELECTROPHORETIC (DEP) CELL FRACTIONATION SYSTEM

机译：集成的微流体介电泳（DEP）细胞分级系统

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In this article we report on a planar miniaturized dielectrophoretic (DEP) microfluidic device developed for the purpose of continuous fractionation and purification of sample suspensions of microscopic particles or biological cells, employing specially shaped nonuniform (isomotive) electric fields. The device integrates three fully functional and distinct sub-units consisting of 1) sheath and sample injection ports, arranged to achieve hydrodynamic focusing of the cell stream; 2) the DEP fractionation region and 3) two sample collection ports. In the DEP fractionation region, the magnitude of the field induced DEP force acting on the particle is essentially constant and independent of the particle's position and furthermore only dependent on the intrinsic polarization response of the particle, for identical sized particles. The operation and performance in terms of sample throughput, separation efficiency and repeatability of the device was evaluated using test microscopic sized dielectric particles and biological particles, including cancerous cell lines.
机译：在本文中，我们报告了用于连续分馏和纯化微观粒子或生物细胞的样品悬浮液的目的开发的平面小型化介电流（DEP）微流体装置，所述微观粒子或生物细胞的样品悬浮液，所述脱脂颗粒或生物细胞的样品悬浮液。该器件集成了三种全功能且不同的子单元，包括1个）护套和样品喷射口，设置成实现电池流的流体动力学聚焦; 2）DEP分级区域和3）两个样品收集端口。在DEP分馏区域中，作用在颗粒上的场诱导的DEP力的大小基本上是恒定的并且与颗粒的位置无关，并且还仅取决于颗粒的内在偏振响应，对于相同的尺寸粒子。使用试验微观尺寸的介电粒子和生物颗粒来评估样品吞吐量，分离效率和可重复性方面的操作和性能，包括癌细胞系。

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