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首页> 外文会议>Asia-Pacific conference on environmental electromagnetics >EFFECTS OF ELECTROMAGNETIC PULSES ON THE BLOOD-BRAIN BARRIER OF RATS
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EFFECTS OF ELECTROMAGNETIC PULSES ON THE BLOOD-BRAIN BARRIER OF RATS

机译：电磁脉冲对大鼠血脑屏障的影响

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Aims: To study the bioeffects off Electromagnetic Pulse (EMP) on Blood-Brain-Barrier (BBB). Methods: Animals were exposed to EMP with field intensity 25, 50, 100, 200 and 400 kV/m, and 25, 50, 100 and 200 pulses; duration between every two pulses is 2s. Firstly, Evans blue (EB) and fluorescent microscope were used to observe the changes in the permeability of BBB after exposed to different combinations of the parameters. Secondly, electron microscope was used to investigate the effects of EMP on the ultrastructure of different area in hippocampus and the marginal division of the brain after injection of lanthanum nitrate. Results: The permeability of BBB of rat can be changed after exposed to EMP with a significant dose-effect relationship. With the increasing of field intensity and rising of pulse number, the number and the area of spots increased so as to the intensity of fluorescent colorations. Morphological changes in BBB and nervous tissue after EMP exposure also showed dose-effect relationship. The lanthanum nitrate granules was appeared in the tissue of cortex, hippocampus and hypothalamus in the EMP exposed group. The process of the granules crossing through the tight junction of capillary vessels and the phagocytosis of the granules in the endothelium cells were presented. Conclusions: Exposure to EMP can lead to increased permeability of BBB and could damage the endothelium cells of the capillary, resulting in increases of the perivascular space of capillary.
机译：目的：研究血脑屏障（BBB）的电磁脉冲（EMP）的生物效应。方法：将动物暴露于抗场强25,50,100,200和400 kV / m和25,50,100和200脉冲的EMP;每两个脉冲之间的持续时间为2s。首先，使用evans蓝（EB）和荧光显微镜观察暴露于参数不同组合后BBB的渗透性的变化。其次，使用电子显微镜来研究EMP对海马不同面积超微结构和脑注射硝酸镧后脑的边际分裂的影响。结果：用显着剂量效应关系暴露于EMP后，可以改变大鼠BBB的渗透率。随着脉冲数的越来越高，斑点的数量和斑点的数量增加到荧光着色的强度。 EMP暴露后BBB和神经组织的形态学也显示出剂量效应关系。在EMP暴露组的皮质，海马和下丘脑的组织中出现了硝酸镧颗粒。呈递通过毛细管的紧密结和内皮细胞中颗粒的吞噬作用的颗粒的过程。结论：暴露于EMP可以导致BBB的渗透性增加，并且可能损害毛细血管内皮细胞，导致毛细管毛细血管空间增加。

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