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Microarray Data Mining Using Gene Ontology

机译:使用基因本体进行微阵列数据挖掘

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DNA microarray technology allows scientists to study the expression of thousands of genes -potentially entire genomes - simultaneously. However the large number of genes, variety of statistical methods employed and the complexity of biologic systems complicate analysis of microarray results. We have developed a web based environment that simplifies the presentation of microarray results by combining microarray results processed for statistical significance with probe set annotation by Genbank, NCBI RefSeqs, GeneCards and the Gene Ontology. This allows rapid examination and classification of microarray experiments - annotated by NCIBI tools - by Statistical Significance and Gene Oncology Classes. By providing a simple, easily understood interface to large microarray data sets, this tool has been particularly useful for small research groups focused on a small number of related genes and for researchers who want to ask simple questions without the overhead of complex data management and analysis.
机译:DNA微阵列技术允许科学家们同时研究全面的全基因组的成千上万基因的表达。然而,大量基因,各种统计方法采用和生物系统的复杂性复杂化微阵列结果。我们开发了一种基于Web的环境,简化了微阵列结果,通过将微阵列结果与Genbank,NCBI Refseqs,Genecards和基因本体的探针集注释组合进行统计显着性。这允许通过NCIBI工具的微阵列实验进行快速检查和分类 - 通过统计显着性和基因肿瘤学课程注释。通过提供大型微阵列数据集的简单,易于理解的界面,该工具对小型研究组特别有用,专注于少数相关基因以及想要在没有复杂数据管理和分析的开销的情况下提出简单问题的研究人员。

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