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Influence of chronic consumption copper 1 maxiumum concentration limits on rats' kidney extra neuronal transmitters' pattern

机译:慢性消费铜1最大浓度限制对大鼠肾额外神经元发射器的影响

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In experiment on 18 rats after 24 weeks of copper 1 MCL water consumption acetylcholine fluorescence was diminished in a kidney, but enlarged in a renal capsule. Catecholamins and serotonin fluorescence in tubules and histamine in all kidney parts was enlarged, and in renal capsule histamine and serotonin fluorescence was decreased. The water load of 6% from body mass after copper reception 24 weeks has reduced of these transmitters fluorescence in a kidney and acetylcholine and histamine in a renal capsule. But it induced augmentation of catecholamins and serotonin fluorescence in a renal capsule. Copper induces inverse changes acetylcholine, histamine, catecholamins and serotonin quantity in a kidney and a renal capsule. By the experiments earlier lead by us with a water load, copper changes the answer of kidney transmitters to water load. Probably from our data follows that the extra neuronal transmitters' quantity is determined more by cellular need, than enzyme systems of transmitters' synthesis state.
机译:在实验18大鼠后24周后铜1 MCL水消耗乙酰胆碱荧光在肾脏中减少,但在肾囊中扩大。在所有肾脏部件中的小管和组胺中的儿茶酚酰胺和血清素荧光被扩大,并且在肾胶囊中,荧光和血清素荧光降低。铜接收后24周后体重的水载荷为6%,在肾囊中的肾脏和乙酰胆碱和组胺中减少了这些发射器荧光。但它诱导了在肾囊中的儿茶酚胺和血清素荧光产生了增强。铜诱导逆变化乙酰胆碱,组胺,儿茶酚酰胺和血清素量在肾脏和肾囊中。通过我们之前的实验通过我们的水负荷,铜改变了肾发射器的答案到水负荷。可能来自我们的数据,遵循额外的神经元发射器的数量比细胞需求更多地确定,而不是发射器合成状态的酶系统。

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