• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-Optics >Modeling of photon migration in the human lung using a finite volume solver
【24h】

Modeling of photon migration in the human lung using a finite volume solver

机译：使用有限卷求解器的人肺在人肺中的光子迁移建模

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The application of the frequency domain and steady-state diffusive optical spectroscopy (DOS) and steady-state near infrared spectroscopy (NIRS) to diagnosis of the human lung injury challenges many elements of these techniques. These include the DOS/NIRS instrument performance and accurate models of light transport in heterogeneous thorax tissue. The thorax tissue not only consists of different media (e.g. chest wall with ribs, lungs) but its optical properties also vary with time due to respiration and changes in thorax geometry with contusion (e.g. pneumothorax or hemothorax). This paper presents a finite volume solver developed to model photon migration in the diffusion approximation in heterogeneous complex 3D tissues. The code applies boundary conditions that account for Fresnel reflections. We propose an effective diffusion coefficient for the void volumes (pneumothorax) based on the assumption of the Lambertian diffusion of photons entering the pleural cavity and accounting for the local pleural cavity thickness. The code has been validated using the MCML Monte Carlo code as a benchmark. The code environment enables a semi-automatic preparation of 3D computational geometry from medical images and its rapid automatic meshing. We present the application of the code to analysis/optimization of the hybrid DOS/NIRS/ultrasound technique in which ultrasound provides data on the localization of thorax tissue boundaries. The code effectiveness (3D complex case computation takes 1 second) enables its use to quantitatively relate detected light signal to absorption and reduced scattering coefficients that are indicators of the pulmonary physiologic state (hemoglobin concentration and oxygenation).
机译：频域和稳态扩散光学光谱（DOS）和稳态近红外光谱（NIRS）的应用诊断人肺损伤挑战这些技术的许多元素。这些包括多均匀胸腔组织中的DOS / NIRS仪器性能和准确的轻型传输模型。胸部组织不仅包括不同介质（例如胸壁，胸壁，肺部），而且其光学性质也随着呼吸的呼吸和胸腔几何的变化而变化（例如气胸部或血管瘤）。本文提出了一种用于在异构复合3D组织中的扩散近似下模拟光子迁移的有限音量求解器。该代码适用涉及菲涅耳反射的边界条件。我们提出了基于在进入胸腔腔的光子的灯泡扩散的假设和局部胸腔厚度的假设基于空隙体积（气胸）的有效扩散系数。使用MCML Monte Carlo Code作为基准测试的代码已被验证。代码环境可以从医学图像和快速自动啮合实现半自动准备3D计算几何体。我们介绍了守则以分析/优化的混合DOS / NIRS /超声技术的应用，其中超声波提供了胸部组织边界的定位数据。代码有效性（3D复杂情况计算需要1秒）使其用于定量地将检测到的光信号与肺部生理状态（血红蛋白浓度和氧合）的指示剂进行定量地叙述。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号