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首页> 外文会议>International Congress of Parasitology >In-vitro antimalarial activities of Withania somnifera, Gymnema sylvestre, Ocimum gratisimum and Cajanus cajan.
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In-vitro antimalarial activities of Withania somnifera, Gymnema sylvestre, Ocimum gratisimum and Cajanus cajan.

机译：Somnifera，Gymnema Sylvestre，OCimum Gratisimum和Cajanus Cajan的体外抗疟疾活动。

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A study was carried out to determine the efficacy of four plants, Withania somnifera (WS), Gymnema sylvestre (GS), Ocimum gratisimum (OG) and Cajanus cajan (CC) traditionally used in the treatment of malaria in Nigeria and India. Ethanolic extracts of these plants were tested in vitro on choloroquine sensitive (MRC-pf-2) and resistant (MRC-pf-303) strains of Plasmodium falciparum for their anti-malarial activity. The IC_(50) values of these plants were calculated and found to be OG (IC_(50) = 23.48 ug/ ml), WS (IC_(50)= 45.24 ug/ ml), GS (IC_(50)= 45.25 ug/ ml) for the pf sensitive strain and CC (IC_(50)= 47.52 ug/ ml) in the pf resistant strain. Others, GS IC_(50)= 69.70 ug/ ml (resistant strain), CC IC_(50) = 72.3lug/ ml (sensitive strain), WS IC_(50)= 88.30 ug/ ml (resistant strain), OG IC_(50)= 121.76ug/ ml (resistant strain). Higher concentrations caused total inhibition of the parasite at the ring stage. Ocimum gratisimum showed the most significant antimalarial effect on the parasites sensitive strain. Results lend some credence to the use of medicinal plants in the treatment of malaria and the need to study the active constituents of effective ones.
机译：进行了一项研究以确定四种植物，含有Somnifera（WS），Gymnema Sylvestre（GS），OC0MEMA Sylvestimul（OG）和CAJANUS CAJAN（CC）传统上用于治疗尼日利亚和印度的疟疾的疗效。这些植物的乙醇提取物在体外测试胆固素敏感（MRC-PF-2）和抗疟药疟原虫的抗性（MRC-PF-303）菌株进行抗疟疾活性。计算这些植物的IC_（50）值，发现是OG（IC_（50）= 23.48ug / ml），WS（IC_（50）= 45.24 UG / mL），GS（IC_（50）= 45.25 UG对于PF抗性菌株的PF敏感菌株和CC（IC_（50）= 47.52ug / ml）的/ mL）。其他，GS IC_（50）= 69.70 ug / ml（抗性应变），CC IC_（50）= 72.3Lug / ml（敏感应变），WS IC_（50）= 88.30 UG / mL（抗性应变），OG IC_（ 50）= 121.76ug / ml（抗性应变）。较高浓度导致环阶段对寄生虫的总抑制。 OCimumLifimum最多对寄生虫敏感菌株的最显着的抗疟疾作用。结果在治疗疟疾治疗中使用药用植物以及研究有效成分的需要。

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