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首页> 外文会议>International Congress of Neuropathology >D-cycloserine reverses recognition deficits in MPTP-induced Parkinson's disease mice model
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D-cycloserine reverses recognition deficits in MPTP-induced Parkinson's disease mice model

机译：D-Cycloserine在MPTP诱导的帕金森病小鼠模型中逆转识别缺陷

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This study investigated behavioral effects of D-cycloserine (DCS) and amantadine (AM) on MPTP-induced Parkinson's disease (PD) mice model. One day after the MPTP lesion, the animals received daily injection of DCS or AM, at the dose of 5 and 10 mg/kg/day. A battery of behavioral test was performed to elucidate motor, cognitive, emotional, and learning function in the mice. MPTP caused a motor impairment, which reversed spontaneously to control levels 10 days after the lesion. However anxiety-like and learning behaviors were not affected by MPTP lesion. Object recognition was suppressed by MPTP, which was ameliorated by the treatment of DCS and AM at the dosage of 10 mg/kg/day. These results suggest that DCS may have beneficial effects on dementia associated with PD.
机译：本研究研究了D-环素（DCS）和氨基胺（AM）对MPTP诱导的帕金森病（Pd）小鼠模型的行为影响。 在MPTP病变后的一天，动物每日注射DC或AM，剂量为5和10mg / kg /天。 进行行为测试的电池，以阐明小鼠的电动机，认知，情绪和学习功能。 MPTP导致电机损伤，其自发反转以在病变后10天控制水平。 然而，焦虑和学习行为不受MPTP病变的影响。 MPTP抑制了对象识别，MPTP通过治疗DCS和AM在10mg / kg /天的剂量中而改善。 这些结果表明DCS对与PD相关的痴呆有益的影响。

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