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首页> 外文会议>NSTI nanotechnology conference and expo >New In Vitro Strategy of Astrocytoma (Astrocytes-like) Cells Treated with Pioglitazone (PPAR gamma agonist) Offers Neuroprotection Against Nanoparticles-lnduced Cytotoxicity
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New In Vitro Strategy of Astrocytoma (Astrocytes-like) Cells Treated with Pioglitazone (PPAR gamma agonist) Offers Neuroprotection Against Nanoparticles-lnduced Cytotoxicity

机译：用Pioglitazone（PPARγ激动剂）处理的星形细胞瘤的新的体外策略（白细胞状）细胞（PPARγ激动剂）为纳米颗粒的神经保护作用是针对纳米颗粒的细胞毒性

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Recently, we and others have developed several cell modsls for the investigation of the molecular mechanisms underlying the cytotoxicity of nanoparticles of metallic and non-metallic oxides. These models allow us to develop a set of strategies whereby critical mammalian cell types (e.g., neural cells) can be protected from the cytotoxicity induced by nanoparticles and other nanomaterials. We have continued to develop cell models in vitro to further elucidate and exploit the putative neuroprotective properties of astrocytes-like astrocytoma cells against the cytotoxicity induced by nanomaterials. We hypothesized that nanoparticle-induced cytotoxic stress can elicit and/or enhance the neuroprotective effects of astrocytes through the activation of astrocytic signaling and alteration of astroglial function. Furthermore, the neuroprotection can be enhanced with pioglitazone. Thus, our results may have pathophysiological implications in neuroprotection and nanotoxicological research.
机译：最近，我们和其他人已经开发了几种细胞MODSL，用于调查金属和非金属氧化物纳米颗粒的细胞毒性下面的分子机制。这些模型允许我们开发一组策略，从而可以保护临数哺乳动物细胞类型（例如，神经细胞）免受纳米颗粒和其它纳米材料诱导的细胞毒性的影响。我们继续在体外开发细胞模型，进一步阐明和利用星形胶质细胞样星形细胞瘤细胞对纳米材料诱导的细胞毒性的推定的神经保护性能。我们假设纳米颗粒诱导的细胞毒性应力可以通过激活星形胶质信号传导和晕厥功能的改变来引发和/或增强星形胶质细胞的神经保护作用。此外，可以用吡格列酮增强神经保护。因此，我们的结果可能具有神经保护和纳米毒理学研究的病理生理影响。

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