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首页> 外文会议>SPIE Conference on Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine >High-speed high-sensitivity spectral-domain correlation mapping optical coherence tomography based modified scanning protocol
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High-speed high-sensitivity spectral-domain correlation mapping optical coherence tomography based modified scanning protocol

机译：基于高速高灵敏度谱系相关映射光学相干断层扫描的修改扫描协议

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摘要

Correlation mapping optical coherence tomography (cmOCT) is an alternative robust method for obtaining volumetric images of dynamic perfusion within the microcirculatory tissue beds in vivo. The cmOCT method uses a 2D correlation mapping algorithm on the intensity OCT images to extract depth resolved flow map from static tissue background. The earlier reported cmOCT was based on a commercial swept-source OCT system, which uses a scanning protocol with dense sampling between adjacent B-frame, such that the inter frame separation was within the resolution limit of the OCT system to ensure strong correlation between adjacent frames. However, this scanning protocol requires a relatively long scan time and high density B-frame images to reconstruct the volumetric perfusion map, which degraded the system performance for fast wide-field in vivo imaging applications. In order to overcome this limitation we implemented a custom built high-speed spectral domain OCT and introduced a new scanning protocol for high-speed and high sensitive imaging of cmOCT. The new scan protocol measures repeated B-scans at the same location to generate a high sensitivity correlation map between successive B-frames. This scanning protocol can provide fast wide scanning with relatively short scanning time.
机译：相关映射光学相干断层扫描（CMOCT）是用于在体内微循环组织床内获得动态灌注体积图像的替代稳健方法。 CMOCT方法在强度OCT图像上使用2D相关映射算法，以从静态组织背景中提取深度分辨流量图。先前报告的CMOCT基于商业扫描源OCT系统，它使用扫描协议具有相邻B帧之间的密集采样的扫描协议，使得帧间间隔在OCT系统的分辨率限制内，以确保相邻之间的强烈相关性框架。然而，该扫描协议需要相对长的扫描时间和高密度B帧图像来重建体积灌注图，这降低了体内成像应用中的快速宽场的系统性能。为了克服这种限制，我们实现了一个定制的高速谱域OCT，并为CMOCT的高速和高敏感成像引入了新的扫描协议。新的扫描协议在相同位置的重复B扫描的反复测量，以在连续的B帧之间产生高灵敏度相关图。该扫描协议可以通过相对短的扫描时间提供快速扫描。

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