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PEGylated Nano-hybrid Adenovirus: Retargeting Adenovirus to Tumor Cells

机译：聚乙二醇化的纳米杂交腺病毒：将腺病毒重新靶向肿瘤细胞

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We have demonstrated that adenovirus can be retargeted to specific tumor cells. By PEGylation with attaching a targeting moiety, innate immune responses were attenuated. Folate-PEG conjugated adenovirus is safe, efficient, and potential carrier for target-specific therapeutic gene delivery.

机译：我们已经证明，腺病毒可以重新靶向特定的肿瘤细胞。通过带有靶向部分的聚乙二醇化，先天免疫应答被减弱。叶酸-PEG共轭腺病毒是安全，有效和潜在的靶标特异性治疗性基因载体。

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《》|2006年|P.467|共1页
会议地点 PittsburghPA(US)
作者
In Kyung Oh; Hyejung Mok; Tae Gwan Park;
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作者单位

Dept. of Biological Science, Korea Advanced Institute of Science and Technology, Daejeon, Yusung gu, Gusung dong 373-1, KOREA;

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原文格式 PDF
正文语种 eng
中图分类生物材料学;
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专利

1. Folate Immobilized and PEGylated Adenovirus for Retargeting to Tumor Cells [J] . In Kyung Oh, Hyejung Mok, Tae Gwan Park Bioconjugate Chemistry . 2006,第3期

机译：叶酸固定化和聚乙二醇化腺病毒用于靶向肿瘤细胞。
2. Noninvasive of adenovirus tumor retargeting in living subjects by a soluble adenovirus receptor-epidermal growth factor (sCAR-EGF) fusion protein. [J] . Liang Q, Kashentseva E, Herschman HR Molecular imaging and biology: MIB : the official publication of the Academy of Molecular Imaging . 2004,第6期

机译：可溶性腺病毒受体-表皮生长因子（sCAR-EGF）融合蛋白可在活体受试者中对腺病毒肿瘤进行无创靶向。
3. Antitumor efficacy of a recombinant adenovirus encoding endostatin combined with an E1B55KD-deficient adenovirus in gastric cancer cells [J] . Li-xia Li, Yan-ling Zhang, Ling Zhou, Journal of Translational Medicine . 2013,第1期

机译：编码内皮抑素的重组腺病毒与E1B55KD缺陷型腺病毒联合在胃癌细胞中的抗肿瘤作用
4. PEGylated Nano-hybrid Adenovirus: Retargeting Adenovirus to Tumor Cells [C] . In Kyung Oh, Hyejung Mok, Tae Gwan Park Society for Biomaterials Transaction Annual Meeting vol.29 pt.2 . 2006

机译：聚乙二醇化的纳米杂交腺病毒：将腺病毒重新靶向肿瘤细胞
5. Adenovirus- and cationic-lipid-mediated intratumoral gene transfer and natural killer cell activity in a SCID mouse melanoma tumor model. [D] . Clark, Paul Robert. 1999

机译：在SCID小鼠黑素瘤肿瘤模型中，腺病毒和阳离子脂质介导的肿瘤内基因转移和自然杀伤细胞活性。
6. Retargeting the Coxsackievirus and Adenovirus Receptor to the Apical Surface of Polarized Epithelial Cells Reveals the Glycocalyx as a Barrier to Adenovirus-Mediated Gene Transfer [O] . Raymond J. Pickles, Jill A. Fahrner, JenniElizabeth M. Petrella, 2000

机译：将柯萨奇病毒和腺病毒受体重定向到极化上皮细胞的根尖表面揭示了糖萼作为腺病毒介导的基因转移的障碍。
7. Retargeting the Coxsackievirus and Adenovirus Receptor to the Apical Surface of Polarized Epithelial Cells Reveals the Glycocalyx as a Barrier to Adenovirus-Mediated Gene Transfer [O] . Pickles, Raymond J., Fahrner, Jill A., Petrella, JenniElizabeth M., 2000

机译：将柯萨奇病毒和腺病毒受体重新定位到极化上皮细胞的顶端表面揭示了糖萼作为腺病毒介导的基因转移的障碍。

PEGylated Nano-hybrid Adenovirus: Retargeting Adenovirus to Tumor Cells

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