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Consensus Properties of the Gene Duplication Problem for Enhanced Phylogenetic Inference

机译:基因重复问题的共识性能提高系统发育推论

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Solving the gene duplication problem is a classical approach for species tree inference from gene trees that are confounded by gene duplications. This problem takes a collection of gene trees and seeks a species tree that implies the minimum number of gene duplications. Wilkinson et al. posed the conjecture that this problem satisfies the desirable Pareto property in 2007. That is, for every instance of the problem, each cluster that is present in all of the input gene trees of this instance, called a consensus cluster, will also be found in every possible solution to this instance. We show that this conjecture does not generally hold. However, we prove that for every instance of the gene duplication problem there is always at least one solution that contains the consensus clusters of the input gene trees. Based on the construction of our proof, we introduce an efficient algorithm that transforms a given species tree into one that implies equal or less duplications, and, in addition, contains all of the consensus clusters. Finally, we demonstrate the performance of our algorithm using simulation studies.
机译:解决基因重复问题是来自基因树的物种树推理的经典方法,这些方法被基因重复混淆。这个问题需要一系列基因树,并寻求一种暗示基因重复数量的物种树。 Wilkinson等人。猜想猜测,这个问题在2007年满足了所需的帕累托属性。即对于问题的每个例子,也将在此实例的所有输入基因树中存在的每个群集称为共识群集,每个可能的解决方案。我们表明,这种猜想通常不会持有。然而,我们证明,对于基因重复问题的各种实例,总是至少有一种包含输入基因树的共识簇的解决方案。基于我们证据的构建,我们介绍了一种高效的算法,它将给定的物种树转换为暗示相同或更少的重复,而且还包含所有共识群集。最后,我们展示了使用模拟研究的算法的性能。

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