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Research on spontaneous activity in adult anisometropic amblyopia with regional homogeneity

机译:具有区域同质性成年嗜型弱视弱视的自发性活性研究

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Amblyopia usually occurs in early childhood and results in monocular visual impairment. The functional magnetic resonance imaging (fMRI) studies have reflected functional anomaly in amblyopia. In resting-state fMRI study, spontaneous activity changes abnormally in anisometropic amblyopia could be revealed by the regional homogeneity (ReHo). Twenty two adult anisometropic amblyopes and Twenty one normal controls participated in this fMRI study. Two sample T test was carried out to analysis ReHo within the whole brain for the inter groups. Compare with normal group, our study found that the amblyopia's ReHo mainly increased in the left frontal lobe, while decreased in the left cerebellum, the temporal lobe (left and right), and the left parietal lobe. And the ReHo values in middle and inferior temporal lobe, the prefrontal lobe, frontal lobe (positive) and parietal lobe and medial frontal gyrus (negative) could be correlated with the acuity deficit of amblyopia. The results increased in ReHo may indicate compensatory plasticity in higher vision information process, while the decreased in ReHo may reflect decreased ability in eye movement, spatial sense and visuo-motor coordination. The correlation revealed that the vision deficit may correspond to the spontaneous in certain brain area.
机译:弱视通常发生在儿童早期,并导致单眼视力障碍。功能性磁共振成像(FMRI)研究反映了弱视中的功能异常。在休息状态的FMRI研究中,区域均匀性(REHO)可以揭示异常杆菌弱视中的自发活性异常变化。二十二个成年人互相弱视和二十一个正常对照参加了这项FMRI研究。进行两种样品T检验,以分析整个大脑内的reho。与正常组相比,我们的研究发现,弱视恢复主要在左前叶中增加,同时在左脑细胞,颞叶(左右)和左侧凸角下降。并且中颞叶中的reho值,前瓣叶,额叶(阳性叶(阳性)和榫叶和内侧圆形回物(阴性)可以与弱视症的敏锐度缺陷相关。结果在REHO中增加的结果可能表明较高视觉信息过程中的补偿可塑性,而恢复的下降可能会反映眼球运动,空间感和潜能电机协调的能力下降。相关性揭示了视觉缺陷可以对应于某些脑区域的自发性。

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