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首页> 外文会议>ASME International Mechanical Engineering Congress and Exposition >PICOLITER FLUIDIC FLOW CHARACTERIZATION USING ION-SELECTIVE MEASUREMENT
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PICOLITER FLUIDIC FLOW CHARACTERIZATION USING ION-SELECTIVE MEASUREMENT

机译：使用离子选择性测量的Picoliter流体流动表征

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Techniques for accurate measurement of liquid flows involving volumes on the order of nanoliters and picoliters are critical for advancement of microfluidics applications. Although several techniques for measurement of microfluidic flows where a liquid is dispensed on to a target are available today, no proven techniques currently exist for measurement of microfluidic flows where a liquid is injected into a liquid media. Motivated by such a measurement need in a current project, this paper presents a novel experimental technique to measure bulk-flow of a liquid dispensed into another liquid medium with sensitivity down to picoliter range. This technique is based on the principle of titration of two liquids and measurement of hydrogen ions in the resulting solution. The critical components of the system that enable the proposed technique are: A highly sensitive hydrogen ion concentration (pH) sensor and a device to dispense very small, calibrated, volumes of liquid. Since commercially available hydrogen ion sensors are bulky for use in the proposed technique, a hydrogen ion sensor element that provides a sensing tip dimension on the order of a few microns is fabricated from a glass capillary for the current study. Dispensing of calibrated volumes of liquid is accomplished by means of a calibrated syringe for volumes in nanoliter range and a glass capillary for volumes in picoliter range, the latter serving as a dispensing port of a diameter of about 2 μm. The paper includes details of experiments where the proposed technique is first applied to precisely predict injections of 20 and 40 nL volumes and then extended to demonstrate the sensitivity of the sensor element to injections of volumes in the picoliter range. The preliminary experimental results presented generally validate the principle involved in this technique and suggest that the technique is virtually scalable to any volume flows typically encountered in the microfluidics applications.
机译：用于精确测量涉及纳米型和皮热仪的量的液体流量的技术对于微流体应用的推进至关重要。尽管今天可​​以获得用于测量液体的微流体流量的几种技术，但目前没有证明的技术用于测量将液体注射到液体介质中的微流体流动。通过这种测量需求在当前项目中的动机，本文提出了一种新的实验技术，用于测量分配到另一个液体介质的液体的体积流动，其敏感性下来至picheriter范围。该技术基于所得溶液中两种液体滴定的原理和氢离子的测量。能够实现所提出的技术的系统的关键组分是：高敏感的氢离子浓度（pH）传感器和用于分配非常小，校准的液体的装置。由于商业上可获得的氢离子传感器用于所提出的技术，因此提供了一种氢离子传感器元件，该氢离子传感器元件在几微米的阶段中提供感测的尖端尺寸，用于用于当前研究的玻璃毛细管。校准的液体的分配通过校准的注射器来完成用于纳米孔范围中的体积和用于Picoliter范围内的玻璃毛细管的玻璃毛细管完成，后者用作直径为约2μm的分配端口。本文包括所提出的技术首先应用于精确地预测20和40个NL体积的实验的细节，然后扩展以证明传感器元件在Picoliter范围内的卷的进射的灵敏度。呈现的初步实验结果通常验证了该技术所涉及的原理，并表明该技术几乎可扩展到Microfluidics应用中通常遇到的任何体积流量。

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