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Keratinocyte Growth Factor Upregulates Integrin Alpha5-beta1 in Epidermal Keratinocytes And Tissue Engineered Skin Equivalents

机译：角膜炎细胞生长因子上调表皮角质细胞和组织工程皮肤等同物中的整联蛋白α5-β1

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Keratinocyte growth factor is a member of the fibroblast growth factor family. It is produced by stromal cells but effects epithelial cells. Its expression is highly upregulated during wound healing. KGF promotes migration of keratinocytes on fibronectin. Since keratinocytes bind through alpha5-beta1 integrin on fibronectin we investigated whether the increase in migration is through this subunit. Using PCR we found that KGF increases a5 mRNA expression in 2D cells cultures as well as 3 D skin equivalents. We found out that KGF enhances wound healing in a 2 dimensional scratch wound assay model. Using function blocking antibody to alpha5 blocked KGF induced increase in migration. The signaling pathway(s) through which KGF mediates alpha5 up regulation is currently under investigation in our laboratory. An understanding of the molecular interactions of KGF with integrins may enable novel strategies in engineering better tissue substitutes for the treatment of burns and chronic wounds.

机译：角质形成细胞生长因子是成纤维细胞生长因子家族的成员。它由基质细胞产生，但效果上皮细胞。其表达在伤口愈合期间高度上调。 KGF促进角蛋白酶的迁移在纤维菌蛋白上。由于角蛋白酶通过α5-β1整合蛋白与纤维蛋白联系我们，我们研究了迁移的增加是否通过该亚基。使用PCR，我们发现KGF在2D细胞培养物中以及3D皮肤等同物中增加A5 mRNA表达。我们发现KGF在2维划痕伤口测定模型中增强了伤口愈合。使用功能阻断抗体对α5阻断KGF诱导迁移增加。 KGF中介alpha5 up调节的信号通路目前正在我们的实验室调查。对kgf与整联蛋白的分子相互作用的理解可以使工程更好的组织替代品能够进行新的策略来治疗烧伤和慢性伤口。

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《AIChE Annual Meeting》|2003年||共3页
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作者
Piyush Koria; Stelios T. Andreadis;
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中图分类 TM911-53;
关键词
KGF; INTEGRINS; SKIN EQUIVALENTS;

机译：KGF;整合蛋白;皮肤等同物;

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专利

1. Integrin expression by human epidermal keratinocytes can be modulated by interferon-gamma, transforming growth factor-beta, tumor necrosis factor-alpha, and culture on a dermal equivalent. [J] . Hertle MD, Jones PH, Groves RW, The Journal of investigative dermatology. . 1995,第2期

机译：人表皮角质形成细胞的整联蛋白表达可以通过干扰素-γ，转化生长因子-β，肿瘤坏死因子-α以及在真皮等效物中的培养来调节。
2. The Neuronal Nitric Oxide Synthase Is Upregulated in Mouse Skin Repair and in Response to Epidermal Growth Factor in Human HaCaT Keratinocytes. [J] . Frank S The Journal of investigative dermatology. . 2004,第1期

机译：神经元一氧化氮合酶在小鼠皮肤修复中和人HaCaT角质形成细胞中对表皮生长因子的响应中上调。
3. Efficient production of bioactive insulin from human epidermal keratinocytes and tissue-engineered skin substitutes: implications for treatment of diabetes. [J] . Lei P, Ogunade A, Kirkwood KL, Tissue engineering . 2007,第8期

机译：由人表皮角质形成细胞和组织工程化的皮肤替代品有效生产生物活性胰岛素：对糖尿病治疗的意义。
4. Keratinocyte Growth Factor Upregulates Integrin Alpha5-beta1 in Epidermal Keratinocytes And Tissue Engineered Skin Equivalents [C] . Piyush Koria, Stelios T. Andreadis AIChE annual meeting . 2003

机译：角质形成细胞生长因子上调表皮角质形成细胞和组织工程皮肤等效物中的整联蛋白Alpha5-beta1
5. Cytokine and growth factor networks associated with epidermal-mesenchymal cell interactions during keratinocyte-stem cell growth in the bovine claw. [D] . Mills, Jason Adam. 2007

机译：细胞因子和生长因子网络与牛爪中角质形成细胞-干细胞生长期间的表皮-间充质细胞相互作用有关。
6. Skin Equivalent Tissue-Engineered Construct: Co-Cultured Fibroblasts/ Keratinocytes on 3D Matrices of Sericin Hope Cocoons [O] . Sunita Nayak, Sancharika Dey, Subhas C. Kundu -1

机译：皮肤等效组织工程构建体：在Sericin Hope茧的3D矩阵上共同培养的成纤维细胞/角质形成细胞
7. Integrin Expression by Human Epidermal Keratinocytes Can Be Modulated by Interferon-γ, Transforming Growth Factor-β, Tumor Necrosis Factor-α, and Culture on a Dermal Equivalent [O] . Hertle Mark D., Jones Philip H., Groves Richard W., 1995

机译：人表皮角质形成细胞的整合素表达可通过干扰素-γ，转化生长因子-β，肿瘤坏死因子-α以及在皮肤等效物中的培养来调节

Keratinocyte Growth Factor Upregulates Integrin Alpha5-beta1 in Epidermal Keratinocytes And Tissue Engineered Skin Equivalents

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