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Indocyanine green-laser thermolysis of acne vulgaris

机译：痤疮寻常痤疮的吲哚菁绿激光热解

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摘要

The near-infrared (NIR) laser radiation due to its high penetration depth is widely used in phototherapy and photothermolysis. In application to skin appendages a high selectivity of laser treatment is needed to prevent light action on surrounding tissues. Indocyanine Green (ICG) dye may provide a high selectivity of treatment due to effective ICG uploading by a target and its narrow band of considerable absorption just at the wavelength of the NIR diode laser. The goal of this study is to demonstrate the efficacy of the NIR diode laser photothermolysis in combination with topical application of ICG suggested for treatment of acne vulgaris. Two volunteers with back-located acne were enrolled. Skin sites of subjects were stained by ICG and irradiated by NIR laser-diode light (803 or 809 nm). The individual acne lesions were photothermally treated at 18 W/cm~2 (803 nm, 0.5 sec) without skin surface cooling or at 200 W/cm~2 (809 nm, 0.5 sec) with cooling. The results of the observations during a month after the treatment have shown that ICG stained acne inflammatory elements were destructed for light exposures of 0.5 sec.
机译：由于其高渗透深度引起的近红外（NIR）激光辐射广泛用于光疗和光热解。在施用于皮肤附属物中，需要高选择性的激光处理，以防止围绕组织的光照动作。由于在NIR二极管激光器的波长下，吲哚菁绿（ICG）染料可以提供高选择性的治疗方法，并且其仅在NIR二极管激光器的波长处上传。本研究的目的是证明NIR二极管激光光热解的疗效与ICG的局部应用组合，建议治疗痤疮寻常痤疮。注册了两个带有背部痤疮的志愿者。受试者的皮肤位点被ICG染色并由NIR激光二极管光（803或809nm）照射。在18W / cm〜2（803nm，0.5秒）的情况下，在没有皮肤表面冷却或在200w / cm〜2（809nm，0.5秒）下，单个痤疮病变在18 w / cm〜2（803nm，0.5秒）下进行冷热处理。治疗后一个月内观察结果表明，ICG染色痤疮炎症元素被破坏为0.5秒的曝光。

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