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首页> 外文会议>Society of Photo-Optical Instrumentation Engineers Proceedings >Small animals bone density and morphometry analysis with a Dual Energy X-Rays absorptiometry bone densitometer using a 2D digital radiographic detector.
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Small animals bone density and morphometry analysis with a Dual Energy X-Rays absorptiometry bone densitometer using a 2D digital radiographic detector.

机译：小型动物骨密度和形态学分析，使用2D数字射线探测器具有双能X射线吸收骨密度计的骨密度分析。

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摘要

The LEXXOS (DMS, Montpellier, France) is the first axial and total body cone beam bone densitometer using a 2D digital radiographic detector. Technical principles and performances for BMD measurements have been presented in previous papers. Bone densitometers are also used on small animals for drug development. In this paper, we show how the LEXXOS system can be adapted to small animals examinations, and its performances are evaluated. At first, in order to take advantage of the whole area of the digital flat panel X-ray detector, the geometrical configuration has been adapted. Secondly, as small animals present low BMD, a specific dual energy calibration has been defined. This adapted system has then been evaluated on two sets of mice: six reference mice and six ovariectomized mice. Each month, these two populations have been examined and the total body BMD has been measured. This evaluation has shown that the right order of BMD magnitude has been obtained and, as expected, BMD increases on the two sets until age of puberty and after this period, decreases significantly for the ovariectomized set. Moreover, the bone image obtained by dual energy processing on LEXXOS presents a radiographic image quality providing with useful complementary information on bone morphometry and architecture.
机译：Lexxos（DMS，Montpellier，法国）是使用2D数字射线照相检测器的第一轴和全身锥形梁骨密度计。之前的论文提出了BMD测量的技术原则和性能。骨密度计也用于小动物进行药物开发。在本文中，我们展示了Lexxos系统如何适应小型动物检查，并评估其性能。首先，为了利用数字平板X射线检测器的整个区域，已经调整了几何构造。其次，随着小动物存在低BMD，已经定义了特定的双能校准。然后在两组小鼠上评估了这种调整的系统：六只参考小鼠和六只卵巢切除小鼠。每个月，已经检查了这两个人口，并衡量了总体BMD。该评估表明，已经获得了BMD幅度的正确顺序，并且正如预期的那样，BMD在两套上增加，直到青春期的年龄和此期间，卵巢切除术套件明显减少。此外，在Lexxos上的双能处理获得的骨图像呈现了射线照相图像质量，其提供有关骨骼形态学和架构的有用互补信息。

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