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Study of the functional state of peripheral vessels in fingers of rheumatological patients by means of laser Doppler flowmetry and cutaneous thermometry measurements

机译：通过激光多普勒流动和皮肤温度测量研究风湿病学患者手指的外周血管功能状态

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Vasospastic disorders are a common class of rheumatic disease. These include syndromes such as vegetative dystonia, Raynaud's syndrome, vibration disease and rheumatoid arthritis among others. The aim of this work is to develop an original method of diagnosing the functional state of peripheral vessels of the fingers, based on the simultaneous recording of LDF- and thermograms during the occlusion test, for determining vascular disorders of rheumatological patients. A diagnostic method was developed for assessing the functional state of the peripheral vessels of fingers, based on carrying out occlusion test in a thermally stabilized environment, with simultaneous recording of signals of laser Doppler flowmetry and skin thermometry. To verify the diagnostic value of the proposed method, a series of experiments were carried out on 41 rheumatological patients: 5 male and 36 females (average age 56.0±12.2 years). The most common diagnoses in the patient group were rheumatoid arthritis, arthrosis, gout and systemic lupus erythematosus. The laser analyser of blood microcirculation "LAKK-02" (SPE "LAZMA" Ltd, Russia) and a custom developed multi-channel thermometry device for low inertia thermometry were used for experimental measurements. The measurements of cutaneous temperature and the index of microcirculation were performed on the distal phalanx of the third finger of the right hand. Occlusion tests were performed with water baths at 25 and 42 °C and a tonometer cuff with a pressure of 200-220 mmHg for 3 min on the upper arm. The results of experimental studies are presented and interpreted. These data indicate a violation of the blood supply regulation in the form of a pronounced tendency towards microvascular vasoconstriction in the fingers. Thus, the response displaying a tendency toward angiospasm among patients in the rheumatological diseases profile group was observed mainly in the most severe cases (49 % of this group). The prospects of the developed diagnostic method of microcirculatory disorders in rheumatic diseases are evaluated. Thus, cutaneous blood microcirculation and temperature measurements performed together can help in diagnosis of the functional state of peripheral vessels both in a healthy state and when expressing pathology.
机译：旋转痉挛性疾病是一种常见的风湿病疾病。这些包括诸如植物患者，雷诺综合征，振动疾病和类风湿性关节炎等综合征。这项工作的目的是开发一种原始方法，依赖于闭塞试验期间的LDF-和热分析图的同时记录手指的外周血管功能状态的原始方法，用于确定风湿病学患者的血管障碍。基于在热稳定环境中进行闭塞试验，开发了一种用于评估手指外周血血管功能状态的诊断方法，同时记录激光多普勒流动性和皮肤温度测量的信号。为了验证所提出的方法的诊断价值，在41例风湿病患者中进行了一系列实验：5名男性和36名女性（平均年龄56.0±12.2岁）。患者组中最常见的诊断是类风湿性关节炎，关节病，痛风和全身性红斑狼疮。用于低惯性温度测量的血微循环“Lakk-02”（SPE“Lazk-02”（SPE“Lazma”Ltd，Russia）和定制的多通道温度装置的激光分析仪用于实验测量。在右手的第三手指的远端氏酚上进行皮肤温度和微循环指数的测量。在25和42°C的水浴和压脉袖带的水浴进行闭塞试验，上臂压力为200-220mmHg的压力3分钟。提出和解释了实验研究的结果。这些数据表明侵犯了在手指中对微血管血管收缩的明显倾向的形式。因此，在最严重的病例（本组的49％）中，观察到表现出风湿病学疾病概况组患者血管痉挛趋势的响应。评估了风湿病中的微循环障碍诊断方法的前景。因此，进行皮肤血微循环和温度测量，可以帮助诊断健康状态和表达病理的外周血函数的功能状态。

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