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Longitudinal 3-Week Tracking Of Blood Glucose Concentration From Thermo-Optical Response Measurements on Human Skin

机译:纵向3周跟踪血糖浓度从热门光学响应测量对人体皮肤进行测量

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We designed a dual-sensor instrument for measuring optical signals from the arms of human volunteers. The instrument had two temperature-controlled localized reflectance optical probes. Each probe had one illumination fiber and four detection fibers at different source-detector distances. The two probes were maintained at 30°C. Thirty seconds after contact with the skin one was heated and the other was cooled at the same rate. The effect of heating and cooling on the signal was measured and correlated with blood glucose concentration. The measurements were performed 3 to 5 times a day for each volunteer over the span of three weeks. The data points from the first two weeks were used to establish a calibration model for each volunteer, which was used to predict glucose values from the third week optical data. Successful calibration was possible for two of the three volunteers.
机译:我们设计了一种用于测量人类志愿者臂的光信号的双传感器仪器。该仪器具有两个温度控制的局部反射光学探针。每个探针在不同的源检测器距离处具有一个照明纤维和四个检测纤维。将两种探针保持在30℃。与皮肤接触后30秒加热,另一个以相同的速率冷却。测量加热和冷却对信号的影响,并与血糖浓度相关。每天测量为每天3至5次,每个志愿者在三周内完成。前两个周的数据点用于为每个志愿者建立校准模型,用于预测来自第三周光学数据的葡萄糖值。三个志愿者中的两个是可能的成功校准。

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