• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Conference on ICONO: Nonlinear Laser Spectroscopy, High Precision Measurements, and Laser Biomedicine and Chemistry >Optical biopsy of non-melanin pigmented cutaneous benign and malignant lesions
【24h】

Optical biopsy of non-melanin pigmented cutaneous benign and malignant lesions

机译：非黑色素色素色素皮肤良性和恶性病变的光学活组织检查

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In recent years, there has been growing interest in the common use of laser-induced autofluorescence (LIAF) and reflectance spectroscopy (RS) to differentiate disease from normal surrounding tissue - so called optical biopsy method. The goals of this work were investigation of cutaneous benign and malignant lesions by the methods of LIAFS and RS. Spectra from healthy skin areas near to the lesion were detected to be used posteriori to reveal changes between healthy and lesion skin spectra. Before spectral measurements lesions were classified clinically and dermatoscopically by specialist (P.T.). After procedures all lesions were excised and were investigated by standard histological methods. The set-up consists of a nitrogen laser (337 nm, 14 μJ, 10 Hz), halogen lamp (400-900 nm, 50 W), lenses, filters, optical fibers, and a microspectrometer (PC2000, "Ocean Optics", USA). A computer controls these systems. The results, obtained were used to develop multispectral diagnostic algorithms based on the most prominent spectral features from the fluorescence and reflectance spectra of the lesions investigated. In comparison between normal skin and different cutaneous lesion types and between lesion types themselves sensitivities and specificities higher than 90 % were achieved in all cases. These results show a perspective possibility to develop an optical biopsy system for diagnosis and differentiation of the benign and malignant non-melanin pigmented cutaneous lesions with wide clinical applications. Non-invasive and high-sensitive in vivo detection by means of appropriate light sources and detectors should be possible, related to real-time determination of existing pathological conditions.
机译：近年来，对激光诱导的自发荧光（LIAF）和反射光谱（RS）的常见使用令人兴趣令人兴趣，以区分疾病来自正常周围的组织 - 所谓的光学活检方法。这项工作的目标是通过LIAFS和Rs的方法调查皮肤良性和恶性病变。检测到病变附近的健康皮肤区域的光谱被用来使用后验，以揭示健康和病变皮肤光谱之间的变化。在光谱测量病变之前，病变通过专家（P.T.）临床和皮肤诊断。在程序后，通过标准组织方法研究所有病变并通过标准组织学方法研究。设置由氮激光（337nm，14μj，10Hz），卤素灯（400-900nm，50 w），透镜，滤波器，光纤和微分光计（PC2000，“Ocean Optics”，美国）。计算机控制这些系统。得到的结果用于基于来自研究病变的荧光和反射光谱的最突出的光谱特征来开发多光谱诊断算法。相比，正常皮肤和不同的皮肤病变类型和病变类型之间，本身在所有情况下都能实现高于90％的敏感性和特异性。这些结果表明，开发具有广泛临床应用的良性和恶性非黑色素色素皮肤病变的诊断和分化的光学活组织检查系统的透视可能性。应通过适当的光源和探测器进行无侵入性和高敏感的体内检测，与现有病理条件的实时测定有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号