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Time-resolved fluorescence measurements for diffuse optical tomography using ultrafast time-correlated single photon counting

机译:使用超快时间相关单光子计数的漫反射光学构装的时间分辨荧光测量

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We develop a novel approach to infer depth information about a small fluorophore-filled inclusion immersed in a scattering medium. It relies on time-resolved measurements of the time of flight distribution of emitted fluorescent photons after short pulse laser excitation. The approach uses a novel numerical constant fraction discrimination technique to assign a stable arrival time to the distribution's early photons. Our experimental results show a linear relationship between these arrival times and the position of the inclusion. This approach will serve as a useful technique in fluorescence diffuse optical tomography.
机译:我们开发一种新的方法来推断出浸入散射介质中的小荧光团填充包合物的深度信息。它依赖于短脉冲激光激发后发出荧光光子的飞行时间的时间分辨测量。该方法使用新颖的数值恒定分数鉴别技术来将稳定的到达时间分配给分布的早期光子。我们的实验结果显示了这些到达时间与包含的位置之间的线性关系。这种方法将作为荧光漫射光学断层扫描中的有用技术。

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