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Extracellular Matrix-Mediated Tube Formation From Isolated Hepatic Sinusoidal Endothelial Cells-Involvement of Rho GTPases and Caveolae

机译：细胞外基质介导的管形成来自rho gtpase和caveolae的分离的肝正弦内皮细胞

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It is twenty seven years since J. Folkman & C. Haudenshild have demonstrated that "capillary tubes" are formed in vitro from the isolated capillary endothelial cells. During these years, a large number of studies have been performed particularly on intrinsic endothelial cell functions required for capillary angiogenesis such as proliferation, migration, adhesion and differentiation, indicating that these functions are regulated through VEGF (vascular eudothelial growth factor), integrins and Rho-mediated actomyosin signaling axis under the interactions with extracellular matrix. In the interactions between endothelial cells and extracellular matrices that are prerequisite for capillary morphogenesis, caveolin-1, the major protein of caveolae plays an essential role for capillary tube formation.

机译：自J. Folkman＆C. Haudenshild已证明“毛细管管”是从分离的毛细管内皮细胞的体外形成的二十七年。在这些年期间，已经进行了大量研究，特别是在毛细血管血管生成所需的内皮细胞功能上进行，例如增殖，迁移，粘附和分化，表明这些功能通过VEGF（血管uudoTial生长因子），整联素和rho调节 - 在与细胞外基质相互作用下介导的肌动酶信号轴。在内皮细胞和细胞外基质之间的相互作用中，毛细血管形态发生的前提，Caveolin-1，Caveolae的主要蛋白质对毛细管形成起重要作用。

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《World Congress for Microcirculation》|2007年||共8页
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M. Oda; H. Yokomori;
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1. Rho modulates hepatic sinusoidal endothelial fenestrae via regulation of the actin cytoskeleton in rat endothelial cells [J] . Hiroaki Yokomori, Kazunori Yoshimura, Shinsuke Funakoshi, Laboratory investigation . 2004,第7期

机译：Rho通过调节大鼠内皮细胞中肌动蛋白的细胞骨架来调节肝窦窦内皮窗
2. Rho modulates hepatic sinusoidal endothelial fenestrae via regulation of the actin cytoskeleton in rat endothelial cells [J] . Hiroaki Yokomori, Kazunori Yoshimura, Shinsuke Funakoshi, Laboratory investigation . 2004,第8期

机译：Rho通过调节大鼠内皮细胞中肌动蛋白的细胞骨架来调节肝窦窦内皮窗
3. VEGF|[sol]|PLGF induces leukemia cell migration via P38|[sol]|ERK1|[sol]|2 kinase pathway, resulting in Rho GTPases activation and caveolae formation [J] . C Casalou, R Fragoso, J F M Nunes, Leukemia . 2007,第7期

机译：VEGF | [sol] | PLGF通过P38 | [sol] | ERK1 | [sol] | 2激酶途径诱导白血病细胞迁移，从而导致Rho GTPases活化和小窝形成
4. Extracellular Matrix-Mediated Tube Formation From Isolated Hepatic Sinusoidal Endothelial Cells-Involvement of Rho GTPases and Caveolae [C] . M. Oda, H. Yokomori World Congress for Microcirculation . 2007

机译：细胞外基质介导的管形成来自肝正弦内皮细胞的rho gtpase和caveolae
5. Adhesion of murine RAW117 lymphoma cells to hepatic sinusoidal endothelial cells: Study of surface molecule interactions under flow and effect of cyclooxygenase and lipoxygenase inhibitors. [D] . Papadimitriou, Minas N. B. 2000

机译：鼠RAW117淋巴瘤细胞与肝窦窦内皮细胞的粘附性：研究在流动和环氧合酶和脂氧合酶抑制剂作用下的表面分子相互作用。
6. Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation [O] . Dora Cavallo-Medved, Deborah Rudy, Galia Blum, -1

机译：活细胞成像显示在管形成过程中内皮细胞小窝中与活性组织蛋白酶B相关的细胞外基质降解
7. Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation. [O] . Cavallo-Medved, Dora, Rudy, Deborah, Galia, Bogyo, 2009

机译：活细胞成像显示，在管形成过程中，内皮细胞小室中的活性组织蛋白酶B与细胞外基质降解有关。
8. Human Mammary Epithelial Cell Transformation by Rho GTPase Through a Novel Mechanism [R] . Band, V. 2009

机译：Rho GTp酶通过新机制转化人乳腺上皮细胞

Extracellular Matrix-Mediated Tube Formation From Isolated Hepatic Sinusoidal Endothelial Cells-Involvement of Rho GTPases and Caveolae

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