Aberrant expression of human sperm protein 17 influence biological behaviors of ovarian cancer cells

机译：人精子蛋白17的异常表达影响卵巢癌细胞的生物学行为

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Human sperm protein 17 has been demonstrated previously a normal testicular proteins aberrantly expressed in neoplastic cells. In the current study, we investigated the aberrant expression of human sperm protein 17(HSp17) in human epithelial ovarian cancer cells and tried to analyze its influences on the cell behaviors, especially cell migration and chemoresistance, by introducing HSp17 cDNA into a human ovarian carcinoma cell line HO8910. Overexpression of HSp17 increased the migration but decreased the chemosensitivity of ovarian carcinoma cells to carboplatin and cisplatin. The results strongly suggest that HSp17 plays a role in metastatic disease and resistance of epithelial ovarian carcinoma to chemotherapy.

机译：已经证明了人体精子蛋白17以前在肿瘤细胞中处于异常表达的正常睾丸蛋白质。在目前的研究中，通过将HSP17 cDNA引入人卵巢癌，研究了人上皮癌细胞中人体精子蛋白17（HSP17）的异常表达，并试图分析其对细胞行为，特别是细胞迁移和化学抑制的影响。细胞系HO8910。 HSP17的过度表达增加了迁移，但降低了卵巢癌细胞对卡铂和顺铂的化学敏感性。结果强烈表明HSP17在转移性疾病和上皮卵巢癌中的抗性作用起化疗。

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《International symposium on medical and pharmaceutical biotechnology》|2009年||共4页
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中图分类生物医学工程;
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epithelial ovarian cancer; sperm protein 17; migration; chemoresistance;

机译：上皮卵巢癌;精子蛋白质17;迁移;化学抑制;

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1. Sperm protein 17 influences the tissue-specific malignancy of clear cell adenocarcinoma in human epithelial ovarian cancer. [J] . Nakazato T, Kanuma T, Tamura T, International journal of gynecological cancer: official journal of the International Gynecological Cancer Society . 2007,第2期

机译：精子蛋白17影响人上皮性卵巢癌中透明细胞腺癌的组织特异性恶性肿瘤。
2. Sperm Protein 17 Expression by Murine Epithelial Ovarian Cancer Cells and Its Impact on Tumor Progression [J] . Qian Gao, Sue D. Xiang, Kirsty Wilson, Cancers . 2018,第8期

机译：鼠卵巢上皮癌细胞表达精子蛋白17及其对肿瘤进展的影响
3. Sperm protein 17 is a suitable target for adoptive T-cell-based immunotherapy in human ovarian cancer. [J] . Chiriva-Internati M, Weidanz JA, Yu Y, Journal of immunotherapy . 2008,第8期

机译：精子蛋白17是人类卵巢癌中基于T细胞的过继免疫疗法的合适靶标。
4. Aberrant expression of human sperm protein 17 influence biological behaviors of ovarian cancer cells [C] . Li Fang-Qiu, Han Yan-Ling, Liu Qun, International Symposium on Medical and Pharmaceutical Biotechnology(医药生物技术国际研讨会) . 2009

机译：人类精子蛋白17的异常表达影响卵巢癌细胞的生物学行为
5. IGF-1 mediates the post-transcriptional regulation of IL-8 gene expression in ovarian cancer cells: A role for the mRNA binding protein HuR. [D] . Verschoor, Meghan. 2009

机译：IGF-1介导卵巢癌细胞中IL-8基因表达的转录后调控：mRNA结合蛋白HuR的作用。
6. Overexpression of human sperm protein 17 increases migration and decreases the chemosensitivity of human epithelial ovarian cancer cells [O] . Fang-qiu Li, Yan-ling Han, Qun Liu, 2009

机译：人类精子蛋白17的过表达增加迁移并降低人类上皮性卵巢癌细胞的化学敏感性
7. Overexpression of human sperm protein 17 increases migration and decreases the chemosensitivity of human epithelial ovarian cancer cells [O] . 2009

机译：人类精子蛋白17的过表达增加迁移并降低人类上皮性卵巢癌细胞的化学敏感性
8. Cell Growth and Survival in Ovarian Epithelial Cancer Project 1: AKT2 Oncogene and Its Associated Protein APBP in Human Ovarian Cancer [R] . Nicosia, S. V. , Cheng, J. Q. 2003

机译：卵巢上皮癌细胞生长和存活项目1：人类卵巢癌中aKT2癌基因及其相关蛋白apBp

Aberrant expression of human sperm protein 17 influence biological behaviors of ovarian cancer cells

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