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首页> 外文会议>ICME International Conference on Complex Medical Engineering >The formation of G-quadruplex in biologically relevant DNA sequences induced by alkaloid
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The formation of G-quadruplex in biologically relevant DNA sequences induced by alkaloid

机译：生物碱诱导的生物学相关DNA序列中的G-Quadruplem

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摘要

Many Guanine-rich DNA sequences are capable of forming G-quadruplex, such as the telomeric chromosomal terminals and the promoters of several genes including c-myc, c-kit and bcl-2 oncogenes. G-quadruplex structure have conspicuous biological significance and hence the ligands which can promote the formation and stabilize G-quadruplex have attracted much attention. In this paper, we have evaluated the abilities of Jatrorrhizine and Chelerythrine in inducing the formation of G-quadruplex employing Circular Dichroism spectroscopy. Our results indicate that Jatrorrhizine can induce Pu18 and c-kit87up to form mixed-type and parallel G-quadruplex respectively. Chelerythrine can induce Pu18 and c-kit87up to form parallel and antiparallel G-quadruplex respectively. Jatrorrhizine and Chelerythrine can induce the switch of Pul8 G-quadruplex in the presence of K~+ from mixed-type to antiparallel and parallel respectively. However, Jatrorrhizine and Chelerythrine can not change the conformation of c-kit87up G-quadruplex in the presence of K~+. From experimental results it is clear that Jatrorrhizine and Chelerythrine may have the potential to inhibit the growth of tumour cell and also can be useful guidelines for the design of anticancer agents.
机译：许多富含富含鸟嘌呤的DNA序列能够形成G-QuadROLPLEX，例如端粒染色体末端和几种基因的启动子，包括C-MYC，C-kit和BCL-2孔子生成剂。 G-Quadwruplex结构具有显着的生物学意义，因此可以促进形成和稳定G-Quadreplex的配体引起了很多关注。在本文中，我们已经评估了Jatrorrhizine和Chelerythrine在诱导G-Quadruplex采用圆形二色性光谱的形成中的能力。我们的结果表明，JATrorrhizine可以诱导PU18和C-KIT87UP分别形成混合型和平行G-QuadRuplex。 Chererythrine可以诱导PU18和C-KIT87UP分别形成平行和反平行的G-Quadruplex。 JATrorrhizine和Chererythrine可以在k〜+的情况下从混合型诱导脉冲8 g-quadruple的开关分别进行反平行和平行。然而，Jatrorrhizine和Chererythrine不能在K〜+存在下改变C-kit87up g-quadruple的构象。根据实验结果，显然，Jatrorrhizine和Chererythrine可能有可能抑制肿瘤细胞的生长，并且还可以是抗癌剂设计的有用指导。

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