Synthesis A Novel Inhibitor of Factor Xa

机译：合成一种因子Xa的新型抑制剂

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Inappropriate thrombus formation in blood vessels causes cardiovascular disease (myocardial infarction, stroke, pulmonary embolism and so on) which is the most common cause of mortality at present. Fxa is an important factor in blood coagulation cascade. It is an effective and safe method to treat blood coagulation diseases by inhibiting FXa to control blood coagulation. In this paper, a new anticoagulant activity FXa inhibitor was synthesized using polypeptide synthesis method in liquidoid from basic materials. Compared with other methods, the new synthesis method applies the fragments condensation can save cost and time, and yield of all reaction was enhanced.

机译：血管中不适当的血栓形成导致心血管疾病（心肌梗塞，中风，肺栓塞等），这是目前最常见的死亡原因。 FXA是血液凝固级联的重要因素。通过抑制FXA来控制血液凝固，是一种有效和安全的方法来治疗血液凝固疾病。本文使用基础材料的液体液中的多肽合成方法合成了一种新的抗凝血活性FXA抑制剂。与其他方法相比，新的合成方法适用碎片冷凝可以节省成本和时间，并提高所有反应的产量。

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《International Conference on Remote Sensing, Environment and Transportation Engineering》|2011年||共3页
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作者
Shen An Xiong; Yang Gen Sheng;
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原文格式 PDF
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中图分类 TP7-53;
关键词
FXa inhibitor; Polypeptide synthesis;

机译：FXA抑制剂;多肽合成;

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1. Edoxaban, a direct factor Xa inhibitor, suppresses tissue-factor induced human platelet aggregation and clot-bound factor Xa in vitro: Comparison with an antithrombin-dependent factor Xa inhibitor, fondaparinux [J] . Honda Yuko, Kamisato Chikako, Morishima Yoshiyuki Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2016,第Null期

机译：直接因子Xa抑制剂Edoxaban在体外抑制组织因子诱导的人血小板聚集和凝块结合因子Xa：与抗凝血酶依赖性因子Xa抑制剂fondaparinux的比较
2. Edoxaban, a direct factor Xa inhibitor, suppresses tissue-factor induced human platelet aggregation and clot-bound factor Xa in vitro: Comparison with an antithrombin-dependent factor Xa inhibitor, fondaparinux [J] . Honda Yuko, Kamisato Chikako, Morishima Yoshiyuki Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2016,第Null期

机译：Edoxaban，一种直接因子Xa抑制剂，抑制组织因子诱导的人血小板聚集和体外凝结因子Xa：与依赖抗凝血酶依赖性因子XA抑制剂的比较，FondAparinux
3. Theoretical Study of Molecular Structure and Physicochemical Properties of Novel Factor Xa Inhibitors and Dual Factor Xa and Factor IIa Inhibitors [J] . Remko Milan, Remkova Anna, Broer Ria Molecules . 2016,第2期

机译：新型因子Xa抑制剂和双因子Xa和因子IIa抑制剂的分子结构和理化性质的理论研究
4. Synthesis a novel inhibitor of factor Xa [C] . Shen An Xiong, Yang Gen Sheng 2011 International Conference on Remote Sensing, Environment and Transportation Engineering . 2011

机译：合成Xa因子抑制剂
5. A new mechanism-driven bypassing strategy for direct factor Xa inhibitors reveals an unexpected property of target specific anticoagulants. [D] . Thalji, Nabil K. 2015

机译：直接因子Xa抑制剂的新机制驱动旁路策略揭示了靶标特异性抗凝剂的出乎意料的特性。
6. Theoretical Study of Molecular Structure and Physicochemical Properties of Novel Factor Xa Inhibitors and Dual Factor Xa and Factor IIa Inhibitors [O] . Milan Remko, Anna Remková, Ria Broer 2016

机译：新型因子Xa抑制剂和双因子Xa和因子IIa抑制剂的分子结构和理化性质的理论研究
7. Theoretical Study of Molecular Structure and Physicochemical Properties of Novel Factor Xa Inhibitors and Dual Factor Xa and Factor IIa Inhibitors [O] . Milan Remko, Anna Remková, Ria Broer 2016

机译：新型因子Xa抑制剂和双因子Xa和因子IIa抑制剂的分子结构和理化性质的理论研究

Synthesis A Novel Inhibitor of Factor Xa

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