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首页> 外文会议>International Conference on Remote Sensing, Environment and Transportation Engineering >Anti-tumor Effect of the Shefouweikang Herbs on Human Gastric Carcinoma Grafted onto Nude Mice
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Anti-tumor Effect of the Shefouweikang Herbs on Human Gastric Carcinoma Grafted onto Nude Mice

机译：Shefouwweikang草药对裸鼠嫁接到裸鼠的人胃癌的抗肿瘤作用

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To explore the anti-tumor effect of the Shenfouweikang in treatment of gastric cancer. Methods: Nude mice grafted with a human gastric adenocarcinoma cell line BGC-823 was used as the experimental model. The mice were divided into three groups, one control and the two drug administration experimental groups. Animals in the two experimental groups received either Shefouweikang or Dele granule over a 60-day period starting at the first day after grafting. Animals received saline as controls. All the mice were sacrificed at 61 days after being grafted. The anti-tumor effect was assessed by two ways: (1) tumor size was periodically measured during the life of the animals and tumor weight was determined by an electron balance immediately after the animals killed. (2) Apoptotic indices (AI) were examined by the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate fluorescence nick end labeling (TUNEL) method and flow cytometric analysis. Results: Compared with controls and Dele granular powder, tumor growth (size and weight) was significantly inhibited with the Shefouweikang decoction treatment (P<0.05). AI in human gastric cancer xenografts nude mice was significantly increased in the Shefouweikang decoction group compared with the controls and Dele granule group. Conclusion: The anti-tumor effect of gastric cancer cell growth in vivo by Shefouweikang herbs is related with induction of the cell apoptosis.
机译：探讨沉Fouwweikang治疗胃癌的抗肿瘤作用。方法：用人胃腺癌细胞系BGC-823接枝的裸鼠用作实验模型。将小鼠分为三组，一种对照和两种药物管理实验组。两种实验组中的动物在接枝后第一天开始的60天内接受了谢芙威康或DELE颗粒。动物接受盐水作为对照。在接枝后61天处死所有小鼠。通过两种方式评估抗肿瘤效应：（1）在动物杀死后立即通过电子平衡测量肿瘤大小的肿瘤大小测量。 （2）通过末端脱氧核苷酸转移酶介导的脱氧尿苷三磷酸荧光碎片末端标记（TUNEL）方法和流式细胞术分析检查凋亡索引（AI）。结果：与对照和DELE颗粒粉相比，肿瘤生长（尺寸和重量）显着抑制了Shefouwweikang煎剂处理（P <0.05）。与对照组和DELE颗粒组相比，乳头Weikang煎剂汤中的人胃癌异种移植物裸鼠显着增加。结论：Shefouwweikang草药体内体内胃癌细胞生长的抗肿瘤作用与细胞凋亡诱导有关。

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