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Association between ACE Gene Polymorphism of Men of Han Nationality in Northern China and the Effects of the HiHiLo Training

机译：中国北方人类人体基因多态性与Hihilo训练的影响

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摘要

To explore the association between Insertion/Deletion polymorphism of the angiotensin converting enzyme (ACE) gene and the effects of HiHiLo (living at high altitude-exercise at high altitude-training at low altitude) training, Seventy-one healthy men of Han nationality in northern China underwent HiHiLo training for 4 weeks. Training programme was as follows: exposure in hypoxic environment (14.5%～14.8%O_2, 10h/day), three times hypoxic training per week (15.4%O_2), and training at sea level. VO_2max and Haemogram were measured before and after the protocol, and the ACE gene I/D polymorphism was detected by PCR. The findings indicated that the frequency of genotypes in the subjects was in Hardy-Weinberg equilibrium. No significant differences were in the baseline VO_2max、 VO_2max/w、 RBC、 HB and HCT among groups. VO_2max、 VO_2max/w、 RBC、 HB and HCT all increased more significantly in total and II、 ID after training than those before the training (P < 0.01), but no significant changes showed in DD (P > 0.05) except HCT. The present study suggested that HiHiLo training could be helpful for developing aerobic ability. Moreover, men carrying II and ID probably were more sensitive to the hypoxic training than those carrying DD.
机译：为探讨血管紧张素转换酶（ACE）基因的插入/缺失多态性和HiHiLo训练的效果之间的关联（生活在高海拔地区，演习在低空高海拔训练）的训练，汉族七十一个健康的男人中国北方经历HiHiLo训练训练4周。培训计划如下：曝光缺氧环境（14.5％〜14.8％O_2，10小时/天），在海平面每周三次低氧训练（15.4％O_2）和培训。 VO_2max和Haemogram之前和协议后进行测定，并通过PCR法检测ACE基因I / d多态性。研究结果表明，在受试者的基因型的频率在Hardy-Weinberg平衡。无显著差异在基准VO_2max，VO_2max / W，RBC，HB和HCT群体。 VO_2max，VO_2max /瓦特，RBC，HB和HCT所有在总的和II，更ID增加显著训练比训练（P之前后<0.01），但显示在DD（P无显著变化>除了HCT 0.05）。目前的研究表明，HiHiLo训练训练可能成为发展的有氧能力很有帮助。此外，男人们手持II和ID可能是比那些带有DD的低氧训练更加敏感。

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