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首页> 外文会议>SPIE Conference on Biomedical Applications in Molecular, Structural, and Functional Imaging >MPI Cell Tracking: What Can We Learn from MRI?
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MPI Cell Tracking: What Can We Learn from MRI?

机译：MPI Cell跟踪：我们可以从MRI学习什么？

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Magnetic resonance imaging (MRI) cell tracking has become an important non-invasive technique to interrogate the fate of cells upon transplantation. At least 6 clinical trials have been published at the end of 2010, all of which have shown that real-time monitoring of the injection procedure, initial engraftment, and short-term biodistribution of cells is critical to further advance the field of cellular therapeutics. In MRI cell tracking, cells are loaded with superparamagnetic iron oxide (SPIO) particles that provide an MRI contrast effect through microscopic magnetic field disturbances and dephasing of protons. Magnetic particle imaging (MPI) has recently emerged as a potential cellular imaging technique that promises to have several advantages over MRI, primarily linear quantification of cells, a higher sensitivity, and "hot spot" tracer identification without confounding background signal. Although probably not fully optimized, SPIO particles that are currently used as MRI contrast agent can be employed as MPI tracer. Initial studies have shown that cells loaded with SPIO particles can give a detectable MP1 signal, encouraging further development of MPI cell tracking.
机译：磁共振成像（MRI）细胞跟踪已成为在移植时询问细胞命运的重要非侵入性技术。在2010年底之前出版了至少6项临床试验，所有这些试验表明，对注射程序，初始植入和短期生物分布的实时监测细胞对于进一步推进细胞治疗域的基础至关重要。在MRI细胞跟踪中，通过微观磁场干扰和质子的去除，用超顺磁性氧化铁（SPIO）颗粒加载细胞，该颗粒通过显微磁场干扰和去除质子提供MRI对比效果。磁性粒子成像（MPI）最近被出现为潜在的蜂窝成像技术，其承诺具有MRI的若干优点，主要是线性定量细胞，更高的灵敏度和“热点”示踪识别而不混淆背景信号。尽管可能没有完全优化，但目前使用的SPIO颗粒可以用作MPI示踪剂。初步研究表明，装有SPIO颗粒的细胞可以给出可检测的MP1信号，令人振奋的MPI单元跟踪进一步发展。

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