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首页> 外文会议>SPIE Conference on Biomedical Applications in Molecular, Structural, and Functional Imaging >Experimental Demonstration of X-Space Magnetic Particle Imaging
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Experimental Demonstration of X-Space Magnetic Particle Imaging

机译：X空间磁颗粒成像的实验证明

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We have developed a new systems theory for analyzing Magnetic Particle Imaging (MPI), x-space MPI, that motivates an image reconstruction technique requiring only a simple scaling and mapping of the raw signal to image space.~1 As a result, reconstruction time scales linearly with image size. Moreover, we expect there to be no noise gain due to performing a matrix inverse. Reconstruction is simple and can be performed in real-time. Furthermore, there is no "System Function" and no requirement to pre-characterize the nanoparticle in the imaging system before imaging. So far, there has not been an experimental test of the x-space theory on an imaging system. In this paper we begin by describing the theoretical signal that we would expect from the imager for a SPIO nanoparticle source. We then construct a small scale MPI imager to test x-space. We conclude with images from the x-space scanner using the iron oxide tracer Resovist. Our preliminary images show 1.6 mm spatial resolution using a 6.0 T/m gradient that closely matches the expected image resolution from x-space theory. In conclusion, our data supports the theory that MPI can be considered a linear, shift invariant system. This bodes well for the future as we scale MPI scanners to human sizes as large images can be reconstructed simply and rapidly.
机译：我们开发了一种用于分析磁粒子成像（MPI），X空间MPI的新系统理论，其激励图像重建技术，只需要一个简单的缩放和原始信号映射到图像空间。〜1，重建时间用图像尺寸线性缩放。此外，由于执行矩阵逆，我们期望在那里没有噪声增益。重建简单，可以实时执行。此外，没有“系统功能”，并且在成像前没有要求在成像系统中预先表征纳米粒子。到目前为止，还没有对成像系统的X空间理论进行实验测试。在本文中，我们首先描述了我们期望的理论信号，以便从成像仪为SPIO纳米粒子源。然后，我们构建一个小规模的MPI成像器来测试X空间。我们使用氧化铁示踪剂RESOVIST与X空间扫描仪的图像结束。我们的初步图像使用6.0 T / M梯度显示1.6 mm空间分辨率，从X空间理论密切匹配预期的图像分辨率。总之，我们的数据支持该理论，即MPI可以被视为线性，换档不变系统。对于未来的，这种Bodes很好，因为我们将MPI扫描仪扩展到人类尺寸，因为可以简单快速地重建大量图像。

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