Sheep pulmonary adenomatosis (SPA)is a naturally occurring pulmonary neoplasm of sheep.After the first outbreak of it in 1985 in Inner Mongolia of China,2 sheep were diagnosed again in 2006.The clinical signs,histological and ultrastructural pathology of two naturally occurring cases(Poll Dorset sheep,3-years old)were investigated by regular pathological method,X-ray and transmission electron microscope in this research.Simultaneously,the dynamic changes of lymphocytes were examined in their peripheral blood by flow cytometry.The results showed that two natural cases produced watery nasal fluid,higher hreath rate than healthy sheep and cloudy-shaped firm lesions in the lungs hy X-ray.Histologically,the secretory epithelial cells in the pulmonary alveoli and epithelial cells of the bronchioli proliferated and formed papillar form that project into the alveoli or bronchioli.The affected pulmonary alveoli epithelial cells were replaced by the large numhers of tumorous cuboidal epithelial cells by transmission electron microscope.The number of CD4+ T lymphocytes of peripheral blood presented a transitorily increase and rapidly decrease subsequently.These results will facilitate the diagnosis and quarantine of SPA,providing an opportunity for future epidemiological research.
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