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首页> 外文会议>International congress on animal hygiene >UV-Irradiation as Potential Tool to Reduce Environmental Pollutions of Sulfonamides Arising from Swine Livestock
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UV-Irradiation as Potential Tool to Reduce Environmental Pollutions of Sulfonamides Arising from Swine Livestock

机译：紫外线照射作为减少猪牲畜产生的磺胺类环境污染的潜在工具

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The present study aims to determine ways to avoid environmental pollution by sulfonamides as test antibiotics,since the frequent use of antimicrobials in animal livestock poses a risk for environmental pollutions.The effect of UV-Iight on the degradation of sulfonamides was studied,as well as the antimicrobial activity and biocompatibility of the irradiation products.Nine sulfonamides were exposed to UV-Iight(UVA ; UVA/UVB )and sunlight to study photo-oxidation.The brilliant-black reduction test with the germ Geobacillus stearothermophilus var.calidolactis C953 was used to study the antimicrobial activity of the degradation products.Furthermore,the impact of the UVA/UVB-irradiation products on cell viability and proliferation of two murine cell lines (fibroblasts and keratinocytes)was investigated.UVA/UVB treatment of several sulfonamides results in degradation of the compounds in different amounts with the highest degradation for sulfathiazole and sulfanilamide.The UVA/UVB light degradation products exhibit no antimicrobial activity.Sun light exposure reveals a similar degradation pattern of the different sulfonamides.UVA-irradiated sulfonamides degrade to a lesser extent (except sulfamethazine).The degrading products exhibited no toxic effects except sulfanilamide in keratinocytes,and altered cell proliferation to a different extent.UVA/UVB light can inactivate sulfonamides in aqueous solutions.Degrading products exhibit no antimicrobial activity anymore and have no impact on cell viability and a low impact on cell proliferation in vitro.Therefore,firstly the treatment of aquacultures with sulfonamides has to be reconsidered,although UV-Iight effects may be restricted to superficial layers of the water and secondly UV-Iight may be a useful tool to reduce the environmental pollution e.g.via manure from pig farms.However,the biocompatibility results have to be used for a detailed toxicological risk assessment and the effect of irradiation product on soil organisms has to be investigated in further studies.
机译：本研究旨在确定磺胺酰胺作为试验抗生素避免环境污染的方法，因为动物牲畜的频繁使用对环境污染的风险产生了危险。研究了UV-iight对磺酰胺的降解的影响，以及照射产品的抗微生物活性和生物相容性。将磺胺酰胺暴露于UV-IIGH（UVA; UVA / UVB）和阳光，以研究光氧化。使用GREABACILLUSSEEARMOHILUS VAR.Calidolactis C953的辉煌 - 黑色还原试验为了研究降解产物的抗微生物活性。诸如此，研究了UVA / UVB辐照产物对两个鼠细胞系（成纤维细胞和角质形成细胞的细胞活力和增殖的影响。uva / UVB处理几种磺胺胺导致降解导致降解不同量的化合物与苏硫酸甲唑和磺胺胺的最高降解。UVA / UVB光降解Dation产品表现出抗微生物活性。灯暴露揭示不同磺胺酰胺的类似降解模式。辐照磺胺酰胺，降低到较小程度（磺胺甲嗪）。除了角质形成细胞中除磺酰胺外，降级产品没有毒性效应，并改变细胞增殖在不同的程度上。uva / uvb光可以在水溶液中灭活磺酰胺。副作用不再具有抗微生物活性并且对细胞活力没有影响，并且在体外对细胞增殖产生低影响。因此，首先是用磺酰胺的水产养殖。因此虽然UV-ig-igher效应可能仅限于水的浅层，但其次UV-iight可能是减少猪场的环境污染EGVIA粪肥的有用工具。然而，生物相容性结果必须用于一种详细的毒理风险评估及辐照产品对土生物的影响H.至于进一步研究。

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