The Effect of SudanⅠon Exressions of CYP 2E1

机译：CYP2E1苏丹宜善表达的影响

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The protein and mRNA of CYP 2E1 are detected by Immunohistochemistry (IHC)and in situ hybridization (ISH).The experiment is to observe the effect of SudanⅠ on expression of CYP 2E1 and hepatic injury.Experimental animals are randomly divided into control group (C group)and Sudan Ⅰ treatment group.The results of IHC examination show that IOD of CYP 2EI protein has increase (P＜0.01 )in livers in Sudan Ⅰ treatment groups and show uptrend in certain dose range.The results of ISH examination show that IOD of CYP 2ElmRNA is significant increase (P＜0.01 )in livers in SudanⅠtreatment groups and show uptrend in certain dose range.The results indicate that SudanⅠ can induce increase of the expressions of CYP 2E1.

机译：免疫组织化学（IHC）检测CYP 2E1的蛋白质和mRNA，原位杂交（ISH）检测。实验是观察苏丹Ⅰ对CYP 2E1和肝损伤表达的影响。实验动物随机分为对照组（C组和苏丹Ⅰ治疗组。IHC检查结果表明，CYP 2EI蛋白的IOD在苏丹Ⅰ治疗组的肝脏中增加（P <0.01），并在某些剂量范围内显示上升趋势。ISH检查结果表明IOD CYP 2ELMRNA在苏丹Ⅰ处理基团的肝脏中显着增加（P <0.01），并在某些剂量范围内显示上升趋势。结果表明，苏丹Ⅰ可以诱导CYP 2E1表达的增加。

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《International congress on animal hygiene》|2013年||共3页
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Li Xiangfeng; Zang Yating; Lu Qin; Cui Yanyan; Niu Xin; Xie Lijun; Wang Weina; Wang Xia; Sun Wenhui; Gao Hong; Zhao Ru; Yan Yulin; Jiang Huan; Chen Gang; Huang Hui; Shao Zhiyong;
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中图分类兽医公共卫生学（家畜卫生学）;
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The Effect of SudanⅠon Exressions of CYP 2E1

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