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首页> 外文会议>Conference on Optical Elastography and Tissue Biomechanics II >Fast Low-Noise Brillouin Spectroscopy Measurements of Elasticity for Corneal Crosslinking
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Fast Low-Noise Brillouin Spectroscopy Measurements of Elasticity for Corneal Crosslinking

机译：快速低噪声布里渊光谱测量角膜交联弹性

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摘要

The Brillouin scattering spectra of biological systems have shown to be inherently related to the intrinsic elasticity and molecular constants of tissues involved. Our approach of combining confocal microscopy and high-resolution Brillouin spectroscopy via a virtual imaging phase array enabled 10-microsecond single-pixel acquisition time without dedicated spatial filtering. Such an approach is adapted via a single-frequency fiber-coupled 780-nm wavelength laser, frequency stabilized by Rb-D2 absorption line, polarization extinction scheme, ASE filtering, heated Rb-vapor Rayleigh-scattering absorbent, and spectroscopic EMCCD camera, unified as CMS-VIPA: confocal virtual-imaging phase array microscope-spectrometer. Steady strengthening of corneal bulk modulus was observed via spectral shifts of Brillouin scattering from 5.0-5.2 GHz in untreated porcine eyes to 5.7-5.9 GHz in ones cross-linked in riboflavin plus UV-A light - at 0.7-0.9 GHz level of enhancement. The cross-linking depths reaching 300-400 microns were measured, as predicted by modeling. A noncontact Brillouin spectroscopic microscopy system for in-vivo corneal elasticity measurement is under development.
机译：生物系统的布里渊散射光谱表明与所涉及组织的内在弹性和分子常数固有。我们通过虚拟成像阶段阵列组合共聚焦显微镜和高分辨率布里渊光谱的方法，使能为10微秒的单像素采集时间而无需专用空间滤波。这种方法通过单频光纤耦合的780nm波长激光，频率通过RB-D2吸收线，偏振消光方案，ASE滤波，加热的RB - 蒸气瑞散散射吸收性，统一的频率稳定作为CMS-VIPA：共聚焦虚拟成像相位阵列显微镜光谱仪。通过从5.0-5.2GHz在未处理的猪眼中从5.0-5.2GHz散射到5.7-5.9GHz在核黄素加上紫外线 - A光 - A型紫外线散射的稳定强化角膜体积模量观察到5.7-5.9GHz - 在0.7-0.9GHz的增强水平。测量达到300-400微米的交联深度，如通过建模所预测的。用于体内角膜弹性测量的非接触式布里渊光谱显微镜系统是开发的。

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