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首页> 外文会议>Conference on Optical Coherence tomography and coherence domain optical methods in biomedicine XX >Optical coherence elastography based on high speed imaging of single-shot laser-induced acoustic waves at 16 kHz frame rate
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Optical coherence elastography based on high speed imaging of single-shot laser-induced acoustic waves at 16 kHz frame rate

机译：基于16 kHz帧速率的单次激光诱导声波高速成像的光学相干弹性术

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摘要

Shear wave OCE (SW-OCE) is a novel technique that relies on the detection of the localized shear wave speed to map tissue elasticity. In this study, we demonstrate high speed imaging to capture single-shot transient shear wave propagation for SW-OCE. The fast imaging speed is achieved using a Fourier domain mode-locked (FDML) high-speed swept-source OCT (SS-OCT) system. The frame rate of shear wave imaging is 16 kHz, at an A-line rate of ～1.62 MHz, enabling the detection of high-frequency shear waves up to 8 kHz in bandwidth. Several measures are taken to improve the phase-stability of the SS-OCT system, and the measured displacement sensitivity is ～10 nanometers. To facilitate non-contact elastography, shear waves are generated with the photo-thermal effect using an ultra-violet pulsed laser. High frequency shear waves launched by the pulsed laser contain shorter wavelengths and carry rich localized elasticity information. Benefiting from single-shot acquisition, each SWI scan only takes 2.5 milliseconds, and the reconstruction of the elastogram can be performed in real-time with ～20 Hz refresh rate. SW-OCE measurements are demonstrated on porcine cornea ex vivo. This study is the first demonstration of an all-optical method to perform real-time 3D SW-OCE. It is hoped that this technique will be applicable in the clinic to obtain high-resolution localized quantitative measurements of tissue biomechanical properties.
机译：剪切波OCE（SW-OCE）是一种依赖于局部剪切波速检测到地图组织弹性的新技术。在这项研究中，我们展示了高速成像以捕获SW-OCE的单次瞬态剪切波传播。使用傅里叶域模式锁定（FDML）高速扫描源OCT（SS-OCT）系统实现快速成像速度。剪切波成像的帧速率为16 kHz，以〜1.62 MHz的A线速率，使得能够在带宽中检测高达8 kHz的高频剪切波。采取几种措施来提高SS-OCT系统的相位稳定性，测量的位移敏感性是约10纳米。为了促进非接触弹性造影，使用紫外脉冲激光器产生剪切波。由脉冲激光发射的高频剪切波包含较短的波长并携带丰富的局部弹性信息。从单次采集中受益，每个SWI扫描只需要2.5毫秒，并且可以使用〜20 Hz刷新率实时进行弹性图的重建。在猪角膜emaea exvivo上证明了SW-OCE测量。本研究是执行实时3D SW-OCE的全光学方法的第一次演示。希望该技术适用于诊所以获得组织生物力学性质的高分辨率局部定量测量。

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