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High sensitivity contrast enhanced optical coherence tomography for functional in vivo imaging

机译:高灵敏度对比增强光学相干断层扫描,用于体内成像功能

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In this study, we developed and applied highly-scattering large gold nanorods (LGNRs) and custom spectral detection algorithms for high sensitivity contrast-enhanced optical coherence tomography (OCT). We were able to detect LGNRs at a concentration as low as 50 pM in blood. We used this approach for noninvasive 3D imaging of blood vessels deep in solid tumors in living mice. Additionally, we demonstrated multiplexed imaging of spectrally-distinct LGNRs that enabled observations of functional drainage in lymphatic networks. This method, which we call MOZART, provides a platform for molecular imaging and characterization of tissue noninvasively at cellular resolution.
机译:在这项研究中,我们开发并施加了高度散射的大型金纳米棒(LGNR)和定制光谱检测算法,用于高灵敏度对比度增强光学相干性断层扫描(OCT)。我们能够在血液中以低至50晚的浓度检测LGNR。我们利用这种血管无血管3D成像的方法,生物小鼠的实体肿瘤深入。另外,我们展示了可释放的光谱分类LGNR的复用成像,使能淋巴结网络中的功能引流的观察。我们称呼莫扎特的该方法提供了用于在细胞分辨率下非侵入组织的分子成像和表征的平台。

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